| Methods for evaluation of peripheral neurovascular dysfunction. | |
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MedLine Citation:
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PMID: 11469707 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Measurement of skin blood flow is a sensitive marker of C-fiber neurovascular dysfunction. It precedes development of abnormalities in diabetes mellitus, correlates with in vivo indices of the metabolic syndrome, and may be a "benchmark" for future studies on agents to improve microvascular dysfunction in diabetes mellitus. Skin blood flow can be measured under basal and stimulated conditions. There are different methods of evaluation. Iontophoresis and microdialysis are novel methods of drug delivery and the latter may be used as a means of extracting analytes in the skin. Theses methods are not invasive (iontophoresis) or minimally invasive (microdialysis). They can be performed repeatedly and safely in most patients. The use of microdialysis may be limited by sampling only water-soluble molecules. An alternative to microdialysis is iontophoresis, which works better with polar molecules. A combination of microdialysis and iontophoresis techniques can be useful in assessment of the pharmacokinetics of polar and nonpolar agents and the physiology and pathophysiology of the skin neurovascular system. |
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Authors:
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A I Vinik; T Erbas; T S Park; K K Pierce; K B Stansberry |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Diabetes technology & therapeutics Volume: 3 ISSN: 1520-9156 ISO Abbreviation: Diabetes Technol. Ther. Publication Date: 2001 |
Date Detail:
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Created Date: 2001-07-25 Completed Date: 2001-08-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100889084 Medline TA: Diabetes Technol Ther Country: United States |
Other Details:
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Languages: eng Pagination: 29-50 Citation Subset: IM |
Affiliation:
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The Leonard Strelitz Diabetes Research Institutes, Department of Internal Medicine, Eastern Virginia Medical School, Norfolk 23510, USA. vinikai@EVMS.EDU |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Diabetic Angiopathies
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diagnosis*,
physiopathology* Diabetic Neuropathies / diagnosis*, physiopathology* Humans Iontophoresis / methods Laser-Doppler Flowmetry Microcirculation / physiopathology* Microdialysis / methods Regional Blood Flow / drug effects Reproducibility of Results Skin / blood supply Vasoconstrictor Agents / diagnostic use Vasodilator Agents / diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Vasoconstrictor Agents; 0/Vasodilator Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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