Document Detail

Methods for evaluation of peripheral neurovascular dysfunction.
MedLine Citation:
PMID:  11469707     Owner:  NLM     Status:  MEDLINE    
Measurement of skin blood flow is a sensitive marker of C-fiber neurovascular dysfunction. It precedes development of abnormalities in diabetes mellitus, correlates with in vivo indices of the metabolic syndrome, and may be a "benchmark" for future studies on agents to improve microvascular dysfunction in diabetes mellitus. Skin blood flow can be measured under basal and stimulated conditions. There are different methods of evaluation. Iontophoresis and microdialysis are novel methods of drug delivery and the latter may be used as a means of extracting analytes in the skin. Theses methods are not invasive (iontophoresis) or minimally invasive (microdialysis). They can be performed repeatedly and safely in most patients. The use of microdialysis may be limited by sampling only water-soluble molecules. An alternative to microdialysis is iontophoresis, which works better with polar molecules. A combination of microdialysis and iontophoresis techniques can be useful in assessment of the pharmacokinetics of polar and nonpolar agents and the physiology and pathophysiology of the skin neurovascular system.
A I Vinik; T Erbas; T S Park; K K Pierce; K B Stansberry
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Diabetes technology & therapeutics     Volume:  3     ISSN:  1520-9156     ISO Abbreviation:  Diabetes Technol. Ther.     Publication Date:  2001  
Date Detail:
Created Date:  2001-07-25     Completed Date:  2001-08-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100889084     Medline TA:  Diabetes Technol Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  29-50     Citation Subset:  IM    
The Leonard Strelitz Diabetes Research Institutes, Department of Internal Medicine, Eastern Virginia Medical School, Norfolk 23510, USA. vinikai@EVMS.EDU
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MeSH Terms
Diabetic Angiopathies / diagnosis*,  physiopathology*
Diabetic Neuropathies / diagnosis*,  physiopathology*
Iontophoresis / methods
Laser-Doppler Flowmetry
Microcirculation / physiopathology*
Microdialysis / methods
Regional Blood Flow / drug effects
Reproducibility of Results
Skin / blood supply
Vasoconstrictor Agents / diagnostic use
Vasodilator Agents / diagnostic use
Reg. No./Substance:
0/Vasoconstrictor Agents; 0/Vasodilator Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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