Document Detail

Methods of evaluating fetal lung maturity.
MedLine Citation:
PMID:  7032844     Owner:  NLM     Status:  MEDLINE    
Respiratory distress syndrome occurs in infants born with immature lungs. The immature fetal lung lacks an adequate supply of surfactant, a phospholipid-rich substance which is produced in the type II cells of the alveolar epithelium. In the fetus, surfactant is secreted into the potential air spaces of the lung and passes into the amniotic fluid as gestation proceeds. It is now clear that most methods currently in use for assessing fetal lung maturity depend on the detection of a sudden release of surfactant into the amniotic fluid as the lung reaches a critical stage of maturity. These methods, which include the lecithin/sphingomyelin ratio, the lung profile, total phospholipid or lecithin concentration, fluorescence depolarization, lamellar body phospholipid concentration, and the "shake" test, are reviewed in the light of recent understanding of the nature of surfactant. In assessing each method, we have examined possible sources of error in performing the test in the laboratory, factors which could theoretically limit its ability to reflect the state of fetal lung maturity and current information regarding its reliability, in terms of clinical performance. Guidelines for future research in this area are also suggested.
L M Brown; C G Duck-Chong
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Critical reviews in clinical laboratory sciences     Volume:  16     ISSN:  1040-8363     ISO Abbreviation:  Crit Rev Clin Lab Sci     Publication Date:  1982  
Date Detail:
Created Date:  1982-03-13     Completed Date:  1982-03-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8914816     Medline TA:  Crit Rev Clin Lab Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  85-159     Citation Subset:  IM    
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MeSH Terms
Amniotic Fluid / analysis,  metabolism
Chromatography, Thin Layer
Fetal Organ Maturity*
Lung / embryology*
Phosphatidylcholines / analysis
Phosphatidylglycerols / analysis
Phospholipids / analysis
Pulmonary Surfactants / analysis,  isolation & purification,  metabolism
Sphingomyelins / analysis
Surface Tension
Reg. No./Substance:
0/Phosphatidylcholines; 0/Phosphatidylglycerols; 0/Phospholipids; 0/Pulmonary Surfactants; 0/Sphingomyelins

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