| Methods of evaluating fetal lung maturity. | |
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MedLine Citation:
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PMID: 7032844 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Respiratory distress syndrome occurs in infants born with immature lungs. The immature fetal lung lacks an adequate supply of surfactant, a phospholipid-rich substance which is produced in the type II cells of the alveolar epithelium. In the fetus, surfactant is secreted into the potential air spaces of the lung and passes into the amniotic fluid as gestation proceeds. It is now clear that most methods currently in use for assessing fetal lung maturity depend on the detection of a sudden release of surfactant into the amniotic fluid as the lung reaches a critical stage of maturity. These methods, which include the lecithin/sphingomyelin ratio, the lung profile, total phospholipid or lecithin concentration, fluorescence depolarization, lamellar body phospholipid concentration, and the "shake" test, are reviewed in the light of recent understanding of the nature of surfactant. In assessing each method, we have examined possible sources of error in performing the test in the laboratory, factors which could theoretically limit its ability to reflect the state of fetal lung maturity and current information regarding its reliability, in terms of clinical performance. Guidelines for future research in this area are also suggested. |
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Authors:
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L M Brown; C G Duck-Chong |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Critical reviews in clinical laboratory sciences Volume: 16 ISSN: 1040-8363 ISO Abbreviation: Crit Rev Clin Lab Sci Publication Date: 1982 |
Date Detail:
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Created Date: 1982-03-13 Completed Date: 1982-03-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8914816 Medline TA: Crit Rev Clin Lab Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 85-159 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amniotic Fluid
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analysis,
metabolism Centrifugation Chromatography, Thin Layer Fetal Organ Maturity* Humans Lung / embryology* Phosphatidylcholines / analysis Phosphatidylglycerols / analysis Phospholipids / analysis Pulmonary Surfactants / analysis, isolation & purification, metabolism Sphingomyelins / analysis Surface Tension |
| Chemical | |
Reg. No./Substance:
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0/Phosphatidylcholines; 0/Phosphatidylglycerols; 0/Phospholipids; 0/Pulmonary Surfactants; 0/Sphingomyelins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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