| Methods for enhancement of sperm function. | |
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MedLine Citation:
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PMID: 9159246 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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From a review of recent advances in human reproduction, it is apparent that therapeutic approaches to male infertility have been revolutionized. While our understanding of sperm function at the molecular level is steadily increasing, the realization of consistent oocyte fertilization by mechanically bypassing natural barriers has given new perspective for future investigation. This chapter reviews current knowledge of adjuvants that enhance sperm function and lend themselves to clinical application. Each compound is presented with recent publications supporting proposed mechanisms of action. Specifically, follicular fluid, progesterone, pentoxifylline, platelet activating factor and other cytokines have been studied for their impact on the in vitro fertilization capacity of spermatozoa. Intracytoplasmic sperm injection (ICSI) has provided infertile couples with hope for successful reproduction without sperm donation. The precise mechanism that allows subsequent pronuclear formation and syngamy is currently unknown and experimental models are few. Adjuvants that can be used in conjunction with controlled ovarian stimulation and intrauterine insemination are prominent areas for further research as this would provide an alternative to the expense and risks of in vitro fertilization and embryo transfer. |
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Authors:
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B S Minhas; B A Ripps |
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Publication Detail:
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Type: Journal Article; Review Date: 1996-08-01 |
Journal Detail:
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Title: Frontiers in bioscience : a journal and virtual library Volume: 1 ISSN: 1093-4715 ISO Abbreviation: Front. Biosci. Publication Date: 1996 |
Date Detail:
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Created Date: 2004-07-09 Completed Date: 2006-03-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9709506 Medline TA: Front Biosci Country: United States |
Other Details:
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Languages: eng Pagination: e65-71 Citation Subset: IM |
Affiliation:
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Assisted Reprodutive Technology, The Center for Human Reproduction, 750 North Orleans, Chicago, IL 60610, USA. bmin19@strarnetinc.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cytokines
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physiology Female Humans Male Sperm Injections, Intracytoplasmic / methods Sperm Motility Sperm-Ovum Interactions / physiology* Spermatozoa / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Cytokines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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