Document Detail

Methods for assessing arterial stiffness: technical considerations.
MedLine Citation:
PMID:  22895411     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: The metabolic and haemodynamic changes associated with chronic kidney disease result in accelerated arterial stiffening which in part explains the high cardiovascular risk associated with this condition. Measurement of arterial stiffness is a useful tool for studying cardiovascular pathophysiology and effects of therapies. Performed well, these techniques are an accurate and efficient way of collecting clinical data, requiring little training and with high repeatability. However, generation of high-quality evidence in this field has been hampered by the use of different techniques, methodological differences, limited comparability between devices and small sample sizes. This review aims to summarize the recent recommendations regarding the best techniques and technicalities of measurement.
RECENT FINDINGS: Aortic pulse wave velocity (PWV) has been recommended as the gold-standard measure of arterial stiffness and new commercially available devices make its measurement more straightforward. To minimize the effect of confounding factors, particularly blood pressure, aortic PWV needs to be measured carefully according to the current recommendations which are outlined in this review.
SUMMARY: These recent recommendations about the measurement of arterial stiffness and ways of comparing values from different devices should lead to rapid growth of epidemiological data and facilitate its use as a clinical tool.
Laurie A Tomlinson
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in nephrology and hypertension     Volume:  21     ISSN:  1473-6543     ISO Abbreviation:  Curr. Opin. Nephrol. Hypertens.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-18     Completed Date:  2013-03-29     Revised Date:  2013-05-02    
Medline Journal Info:
Nlm Unique ID:  9303753     Medline TA:  Curr Opin Nephrol Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  655-60     Citation Subset:  IM    
Department of Clinical Pharmacology, Addenbrooke's Hospital, Cambridge, UK.
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MeSH Terms
Aorta / physiopathology*
Blood Pressure
Equipment Design
Predictive Value of Tests
Pulse Wave Analysis* / instrumentation
Renal Insufficiency, Chronic / diagnosis*,  epidemiology,  physiopathology
Reproducibility of Results
Vascular Stiffness*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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