Document Detail


Methods of the pharmacological imaging of the cannabinoid system (PhICS) study: towards understanding the role of the brain endocannabinoid system in human cognition.
MedLine Citation:
PMID:  21574207     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Various lines of (pre)clinical research indicate that cannabinoid agents carry the potential for therapeutic application to reduce symptoms in several psychiatric disorders. However, direct testing of the involvement of cannabinoid brain systems in psychiatric syndromes is essential for further development. In the Pharmacological Imaging of the Cannabinoid System (PhICS) study, the involvement of the endocannabinoid system in cognitive brain function is assessed by comparing acute effects of the cannabinoid agonist Δ9-tetrahydrocannabinol (THC) on brain function between healthy controls and groups of psychiatric patients showing cognitive dysfunction. This article describes the objectives and methods of the PhICS study and presents preliminary results of the administration procedure on subjective and neurophysiological parameters. Core elements in the methodology of PhICS are the administration method (THC is administered by inhalation using a vaporizing device) and a comprehensive use of pharmacological magnetic resonance imaging (phMRI) combining several types of MRI scans including functional MRI (fMRI), Arterial Spin Labeling (ASL) to measure brain perfusion, and resting-state fMRI. Additional methods like neuropsychological testing further specify the exact role of the endocannabinoid system in regulating cognition. Preliminary results presented in this paper indicate robust behavioral and subjective effects of THC. In addition, fMRI paradigms demonstrate activation of expected networks of brain regions in the cognitive domains of interest. The presented administration and assessment protocol provides a basis for further research on the involvement of the endocannabionoid systems in behavior and in psychopathology, which in turn may lead to development of therapeutic opportunities of cannabinoid ligands.
Authors:
Hendrika H van Hell; Matthijs G Bossong; Gerry Jager; René S Kahn; Nick F Ramsey
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of methods in psychiatric research     Volume:  20     ISSN:  1557-0657     ISO Abbreviation:  Int J Methods Psychiatr Res     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-05-16     Completed Date:  2011-09-30     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  9111433     Medline TA:  Int J Methods Psychiatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  10-27     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 John Wiley & Sons, Ltd.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Attention / drug effects
Brain / blood supply*,  drug effects,  metabolism*
Brain Mapping*
Cannabinoid Receptor Modulators / metabolism*
Cognition / drug effects,  physiology*
Double-Blind Method
Dronabinol / blood,  therapeutic use
Emotions / drug effects
Endocannabinoids*
Heart Rate / drug effects
Humans
Image Processing, Computer-Assisted
Intelligence
Magnetic Resonance Imaging / methods
Mental Disorders / blood,  drug therapy,  pathology,  physiopathology
Neuropsychological Tests
Oxygen / blood
Pain Measurement
Personality / drug effects
Psychotropic Drugs / blood,  therapeutic use
Randomized Controlled Trials as Topic
Reward
Spin Labels
Time Factors
Chemical
Reg. No./Substance:
0/Cannabinoid Receptor Modulators; 0/Endocannabinoids; 0/Psychotropic Drugs; 0/Spin Labels; 7J8897W37S/Dronabinol; S88TT14065/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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