Document Detail

Methodology for studying postprandial lipid metabolism.
MedLine Citation:
PMID:  17457341     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Postprandial lipid metabolism in humans has deserved much attention during the last two decades. Although fasting lipid and lipoprotein parameters reflect body homeostasis to some extent, the transient lipid and lipoprotein accumulation that occurs in the circulation after a fat-containing meal highlights the individual capacity to handle an acute fat input. An exacerbated postprandial accumulation of triglyceride-rich lipoproteins in the circulation has been associated with an increased cardiovascular risk. METHODS: The important number of studies published in this field raises the question of the methodology used for such postprandial studies, as reviewed. RESULTS: Based on our experiences, the present review reports and discuss the numerous methodological issues involved to serve as a basis for further works. These aspects include aims of the postprandial tests, size and nutrient composition of the test meals and background diets, pre-test conditions, characteristics of subjects involved, timing of sampling, suitable markers of postprandial lipid metabolism and calculations. CONCLUSION: In conclusion, we stress the need for standardization of postprandial tests.
D Lairon; J Lopez-Miranda; C Williams
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2007-04-25
Journal Detail:
Title:  European journal of clinical nutrition     Volume:  61     ISSN:  0954-3007     ISO Abbreviation:  Eur J Clin Nutr     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-03     Completed Date:  2008-01-22     Revised Date:  2008-09-24    
Medline Journal Info:
Nlm Unique ID:  8804070     Medline TA:  Eur J Clin Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  1145-61     Citation Subset:  IM    
UMR INSERM 476 Nutrition Humaine et lipides, Faculté de médecine, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France.
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MeSH Terms
Area Under Curve
Biological Markers
Dietary Fats / administration & dosage*,  metabolism*
Lipid Metabolism / physiology*
Lipid Metabolism Disorders / diagnosis*
Particle Size
Patient Selection
Postprandial Period / physiology
Reg. No./Substance:
0/Biological Markers; 0/Dietary Fats
Erratum In:
Eur J Clin Nutr. 2008 Sep;62(9):1154

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