Document Detail

Methodology and results of intravenous thrombolysis in acute myocardial infarction.
MedLine Citation:
PMID:  3100039     Owner:  NLM     Status:  MEDLINE    
For the vast majority of patients with acute myocardial infarction, intravenous thrombolysis is at present the only therapeutic approach aimed at early reperfusion of the ischemic myocardium. Rapid recanalization of the infarct-related coronary artery is achieved in at least 50-60% of the patients by short-term high-dose infusions of streptokinase or urokinase with a low risk of bleeding. A substantial reduction of infarct size, however, can be expected in only a minority of patients, mostly in those who are treated very early. The effects of intravenous thrombolysis on early and late mortality from acute myocardial infarction are still equivocal; more conclusive data may be expected from ongoing randomized trials.
K L Neuhaus
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiovascular and interventional radiology     Volume:  9     ISSN:  0174-1551     ISO Abbreviation:  Cardiovasc Intervent Radiol     Publication Date:  1986  
Date Detail:
Created Date:  1987-03-12     Completed Date:  1987-03-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8003538     Medline TA:  Cardiovasc Intervent Radiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  253-7     Citation Subset:  IM    
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MeSH Terms
Infusions, Intravenous
Myocardial Infarction / drug therapy*,  mortality
Streptokinase / administration & dosage*
Urokinase-Type Plasminogen Activator / administration & dosage
Reg. No./Substance:
EC 3.4.-/Streptokinase; EC Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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