Document Detail


Methodological problems in placental morphometry: apologia for the use of stereology based on sound sampling practice.
MedLine Citation:
PMID:  3070535     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Several problem areas in morphometry of human and animal placentae are reviewed. Attention is given to methods of tissue processing (handling, mode of fixation, embedding, shrinkage) and sampling (of organs, tissue blocks, sections, micrographs). Principal sources of bias and sampling variability are identified and the crucial importance of randomized sampling is emphasized. Methods for obtaining structural quantities from sections are compared. The case is made for estimating absolute values (volumes, surface areas, lengths, numbers, thicknesses) using stereological principles rather than relying on planar data (profile areas, perimeter lengths, numbers, apparent thicknesses). Absolute values may be obtained simply and efficiently without resort to expensive measuring devices. Finally, morphological descriptors suitable for correlating with functional data or for comparing normal and diseased organs are surveyed.
Authors:
T M Mayhew; G J Burton
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Placenta     Volume:  9     ISSN:  0143-4004     ISO Abbreviation:  Placenta     Publication Date:    1988 Nov-Dec
Date Detail:
Created Date:  1989-04-26     Completed Date:  1989-04-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  565-81     Citation Subset:  IM    
Affiliation:
Department of Anatomy, Marischal College, University of Aberdeen, UK.
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MeSH Terms
Descriptor/Qualifier:
Delivery, Obstetric
Female
Histological Techniques
Humans
Organ Size
Placenta / analysis*,  pathology
Pregnancy
Tissue Survival

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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