| Methodological considerations for analyzing trabecular architecture: an example from the primate hand. | |
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MedLine Citation:
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PMID: 20977475 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Micro-computed tomographic analyses of trabecular bone architecture have been used to clarify the link between positional behavior and skeletal anatomy in primates. However, there are methodological decisions associated with quantifying and comparing trabecular anatomy across taxa that vary greatly in body size and morphology that can affect characterizations of trabecular architecture, such as choice of the volume of interest (VOI) size and location. The potential effects of these decisions may be amplified in small, irregular-shaped bones of the hands and feet that have more complex external morphology and more heterogeneous trabecular structure compared to, for example, the spherical epiphysis of the femoral head. In this study we investigate the effects of changes in VOI size and location on standard trabecular parameters in two bones of the hand, the capitate and third metacarpal, in a diverse sample of nonhuman primates that vary greatly in morphology, body mass and positional behavior. Results demonstrate that changes in VOI location and, to a lesser extent, changes in VOI size had a dramatic affect on many trabecular parameters, especially trabecular connectivity and structure (rods vs. plates), degree of anisotropy, and the primary orientation of the trabeculae. Although previous research has shown that some trabecular parameters are susceptible to slight variations in methodology (e.g. VOI location, scan resolution), this study provides a quantification of these effects in hand bones of a diverse sample of primates. An a priori understanding of the inherent biases created by the choice of VOI size and particularly location is critical to robust trabecular analysis and functional interpretation, especially in small bones with complex arthroses. |
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Authors:
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Tracy L Kivell; Matthew M Skinner; Richard Lazenby; Jean-Jacques Hublin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-26 |
Journal Detail:
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Title: Journal of anatomy Volume: 218 ISSN: 1469-7580 ISO Abbreviation: J. Anat. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-06 Completed Date: 2011-03-14 Revised Date: 2013-04-08 |
Medline Journal Info:
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Nlm Unique ID: 0137162 Medline TA: J Anat Country: England |
Other Details:
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Languages: eng Pagination: 209-25 Citation Subset: IM |
Copyright Information:
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© 2010 The Authors. Journal of Anatomy © 2010 Anatomical Society of Great Britain and Ireland. |
Affiliation:
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Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany. tracy_kivell@eva.mpg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anthropology, Physical / methods Capitate Bone / anatomy & histology*, radiography Metacarpal Bones / anatomy & histology*, radiography Primates / anatomy & histology* X-Ray Microtomography |
| Comments/Corrections | |
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