| Methodological aspects of short-term knemometry in the assessment of exogenous glucocorticosteroid-induced growth suppression in children. | |
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MedLine Citation:
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PMID: 9395739 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During recent years knemometry has been introduced for short-term assessment of the growth-suppressive effect of exogenous glucocorticosteroids in children. The aim of the present paper is to review methodological aspects of short-term knemometry used for this purpose. Knemometry has proven a highly accurate and reproducible method for assessment of short-term growth suppression in populations of children treated with exogenous glucocorticosteroids. Randomized, double-blind crossover and parallel designs applying consistent measurement intervals can be used. Confounding influences on the growth results from possible inter-group differences in spontaneous growth velocities are reduced in the crossover design. Glucocorticosteroid-induced knemometric growth suppression seems to reflect suppressive effects on soft tissue and bone components in the lower leg. In children treated with systemic glucocorticosteroids a shortening of the lower leg, which may be due to a reduction of the water content in the soft tissue, may confound the growth assessment. Suppressed short-term growth rates should be considered to have a poor correlation with long-term growth, though prospectively planned, controlled studies of the relation are needed in glucocorticosteroid-treated children. |
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Authors:
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O D Wolthers |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of human biology Volume: 24 ISSN: 0301-4460 ISO Abbreviation: Ann. Hum. Biol. Publication Date: 1997 Nov-Dec |
Date Detail:
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Created Date: 1997-12-29 Completed Date: 1997-12-29 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0404024 Medline TA: Ann Hum Biol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 539-46 Citation Subset: IM |
Affiliation:
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Randers Hospital, Denmark. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bone Development
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drug effects Child Dose-Response Relationship, Drug Glucocorticoids / adverse effects* Growth / drug effects* Humans |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids |
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