Document Detail


Methodological aspects of a clinical trial in chronic lymphocytic leukemia: necessity to develop new biostatistical methods.
MedLine Citation:
PMID:  2099405     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The CLL protocol allowed a better understanding of the natural history of Chronic Lymphocytic Leukemia and an assessment of several treatment strategies. From the point of view of biostatistical research, it raised several important problems. In this paper, we show the interest of applying sequential methods, particularly the triangular test. Other biostatistical problems raised by the CLL 80 protocol are still not, or only partially, resolved. They include taking into account prior belief about treatment benefit in sample size calculations, using surrogate endpoints, developing methods to take into account the causes of death, to analyse repeated measurements, and to assess and compare staging systems.
Authors:
S Chevret; J Benichou; C Chastang
Related Documents :
10709805 - Conditional and exact tests in crossover trials.
12689735 - Estimating the distribution of nonterminal event time in the presence of mortality or i...
17591655 - Pharmacological models in healthy volunteers: their use in the clinical development of ...
3838715 - A fortran program for the design and analysis of sequential clinical trials.
18479265 - Multiplicative random regression model for heterogeneous variance adjustment in genetic...
24788945 - Quantifying extinction probabilities from sighting records: inference and uncertainties.
Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Review    
Journal Detail:
Title:  Nouvelle revue française d'hématologie     Volume:  32     ISSN:  -     ISO Abbreviation:  Nouv Rev Fr Hematol     Publication Date:  1990  
Date Detail:
Created Date:  1991-08-05     Completed Date:  1991-08-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7909092     Medline TA:  Nouv Rev Fr Hematol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  327-31     Citation Subset:  IM    
Affiliation:
Départment de Biostatistique et Informatique Médicale, Hôpital Saint-Louis, Paris, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Biometry / methods
Clinical Protocols
Humans
Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy*
Research Design

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Evidence that the B lymphocyte proliferating in B-CLL and in other B-cell malignancies is frequently...
Next Document:  Role of HLA class II molecules expressed on hematopoietic progenitor cells.