Document Detail

Methodological aspects of a clinical trial in chronic lymphocytic leukemia: necessity to develop new biostatistical methods.
MedLine Citation:
PMID:  2099405     Owner:  NLM     Status:  MEDLINE    
The CLL protocol allowed a better understanding of the natural history of Chronic Lymphocytic Leukemia and an assessment of several treatment strategies. From the point of view of biostatistical research, it raised several important problems. In this paper, we show the interest of applying sequential methods, particularly the triangular test. Other biostatistical problems raised by the CLL 80 protocol are still not, or only partially, resolved. They include taking into account prior belief about treatment benefit in sample size calculations, using surrogate endpoints, developing methods to take into account the causes of death, to analyse repeated measurements, and to assess and compare staging systems.
S Chevret; J Benichou; C Chastang
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Review    
Journal Detail:
Title:  Nouvelle revue française d'hématologie     Volume:  32     ISSN:  -     ISO Abbreviation:  Nouv Rev Fr Hematol     Publication Date:  1990  
Date Detail:
Created Date:  1991-08-05     Completed Date:  1991-08-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7909092     Medline TA:  Nouv Rev Fr Hematol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  327-31     Citation Subset:  IM    
Départment de Biostatistique et Informatique Médicale, Hôpital Saint-Louis, Paris, France.
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MeSH Terms
Biometry / methods
Clinical Protocols
Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy*
Research Design

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