| Method for quantitative mapping of dynamic MRI contrast agent uptake in human tumors. | |
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MedLine Citation:
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PMID: 11599071 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A method is presented for the acquisition and analysis of dynamic contrast-enhanced (DCE) MRI data, focused on the characterization of tumors in humans. Gadolinium (Gd) contrast was administered by bolus injection, and its effect was monitored in time by fast T1-weighted MRI. A simple algorithm was developed for automatic extraction of the arterial input function (AIF) from the DCE-MRI data. This AIF was used in the pixelwise pharmacokinetic determination of physiological vascular parameters in normal and tumor tissue. Maps were reconstructed to show the spatial distribution of parameter values. To test the reproducibility of the method 11 patients with different types of tumors were measured twice, and the rate of contrast agent uptake in the tumor was calculated. The results show that normalizing the DCE-MRI data using individual coregistered AIFs, instead of one common AIF for all patients, substantially reduces the variation between successive measurements. It is concluded that the proposed method enables the reproducible assessment of contrast agent uptake rates. |
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Authors:
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M Rijpkema; J H Kaanders; F B Joosten; A J van der Kogel; A Heerschap |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 14 ISSN: 1053-1807 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2001 Oct |
Date Detail:
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Created Date: 2001-10-12 Completed Date: 2001-12-10 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 457-63 Citation Subset: IM |
Copyright Information:
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Copyright 2001 Wiley-Liss, Inc. |
Affiliation:
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Department of Radiology 430, University Medical Center Nijmegen, Geert Grooteplein 10, 6500 NB Nijmegen, The Netherlands. M.Rijpkema@rdiag.azn.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Brain Neoplasms / metabolism Contrast Media / pharmacokinetics* Gadolinium / pharmacokinetics Head and Neck Neoplasms / metabolism Humans Magnetic Resonance Imaging* Male Neoplasms / metabolism* Prostatic Neoplasms / metabolism Reproducibility of Results Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 7440-54-2/Gadolinium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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