| Method for improving the accuracy of quantitative cerebral perfusion imaging. | |
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MedLine Citation:
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PMID: 15834910 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To improve the accuracy of dynamic susceptibility contrast (DSC) measurements of cerebral blood flow (CBF) and volume (CBV). MATERIALS AND METHODS: In eight volunteers, steady-state CBV (CBV(SS)) was measured using TrueFISP readout of inversion recovery (IR) before and after injection of a bolus of contrast. A standard DSC (STD) perfusion measurement was performed by echo-planar imaging (EPI) during passage of the bolus and subsequently used to calculate the CBF (CBF(DSC)) and CBV (CBV(DSC)). The ratio of CBV(SS) to CBV(DSC) was used to calibrate measurements of CBV and CBF on a subject-by-subject basis. RESULTS: Agreement of values of CBV (1.77 +/- 0.27 mL/100 g in white matter (WM), 3.65 +/- 1.04 mL/100 g in gray matter (GM)), and CBF (23.6 +/- 2.4 mL/(100 g min) in WM, 57.3 +/- 18.2 mL/(100 g min) in GM) with published gold-standard values shows improvement after calibration. An F-test comparison of the coefficients of variation of the CBV and CBF showed a significant reduction, with calibration, of the variability of CBV in WM (P < 0.001) and GM (P < 0.03), and of CBF in WM (P < 0.0001). CONCLUSION: The addition of a CBV(SS) measurement to an STD measurement of cerebral perfusion improves the accuracy of CBV and CBF measurements. The method may prove useful for assessing patients suffering from acute stroke. |
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Authors:
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Ken E Sakaie; Wanyong Shin; Kenneth R Curtin; Richard M McCarthy; Ty A Cashen; Timothy J Carroll |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 21 ISSN: 1053-1807 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2005 May |
Date Detail:
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Created Date: 2005-04-21 Completed Date: 2005-07-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 512-9 Citation Subset: IM |
Affiliation:
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Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60611, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Flow Velocity Blood Volume Determination Brain / blood supply* Calibration Contrast Media Female Gadolinium DTPA / diagnostic use Humans Magnetic Resonance Imaging / methods* Male |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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