Document Detail

Methionine adenosyltransferase deficiency: new enzymatic defect associated with hypermethioninemia.
MedLine Citation:
PMID:  4421454     Owner:  NLM     Status:  MEDLINE    
A specific deficiency of methionine adenosyltransferase has been demonstrated in the liver of an infant with hypermethioninemia. Since the enzymatic activity was below that in fetal liver and the metabolic abnormality has persisted (the infant now being 1 year of age), there is probably a genetic mutation. Mass screening for hypermethioninemia may uncover more such cases.
G E Gaull; H H Tallan
Related Documents :
23213124 - Necrotising enterocolitis in a full-term infant with reversed diastolic flow in the des...
24313094 - The clinical management of preterm infants with bronchiolitis.
21211914 - Mechanical-tactile stimulation (mts) during neonatal stress prevents hyperinsulinemia d...
19325554 - Hepatitis associated with micafungin use in a preterm infant.
21974484 - Developmental changes in ultrasonic vocalizations by infant japanese echolocating bats,...
23911334 - Transplacentally transferred functional antibodies against plasmodium falciparum decrea...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  186     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1974 Oct 
Date Detail:
Created Date:  1974-12-28     Completed Date:  1974-12-28     Revised Date:  2007-08-17    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  59-60     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amino Acid Metabolism, Inborn Errors / blood,  diagnosis,  enzymology*,  genetics
Hydro-Lyases / metabolism
Infant, Newborn
Liver / embryology,  enzymology*
Lyases / metabolism
Mass Screening
Methionine / blood*,  metabolism
Methyltransferases / metabolism
Transferases / deficiency*
Reg. No./Substance:
63-68-3/Methionine; EC 2.-/Transferases; EC 2.1.1.-/Methyltransferases; EC 4.-/Lyases; EC 4.2.1.-/Hydro-Lyases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The interactions of proinsulin with insulin receptors on the plasma membrane of the liver.
Next Document:  Brisk and sluggish concentrically organized ganglion cells in the cat's retina.