| Methionine Diet-induced Hyperhomocysteinemia accelerates cerebral aneurysm formation in rats. | |
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MedLine Citation:
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PMID: 21382440 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: The pathophysiology of cerebral aneurysms (CA) is linked to chronic inflammation.Endothelial damage is one of the first changes in CA walls resulted from inflammation.It has been shown that increase in plasma homocysteine (Hcy) impairs vascular endothelium and correlates with the development of atherosclerosis.However,the effect of hyperhomocysteinemia (HHcy) on the formation of cerebral aneurysm remains unknown. METHODS: Male Sprague-Dawley rats examined for developing cerebral aneurysms after surgical induction in the presence and absence of hypercysteinemia induced by a high L-methionine diet (1g/kg/d).Aneurysms developed at the anterior cerebral-olfactory artery bifurcation were classified as 4 stages from no abnormality to saccular aneurysm.Plasma homocysteine levels and expression of vascular endothelial growth factor (VEGF),endothelial nitric oxide synthase (eNOS),inducible nitric oxide synthase (iNOS),matrix metalloproteinase-2 (MMP-2),and MMP-9 in aneurysmal walls was examined and correlated with CA formation 3months after surgery. RESULTS: Methionine diet significantly increased plasma homocysteine levels,accelerates CA formation after ligation of the left common carotid artery.Expression of VEGF,iNOS,MMP-2,and MMP-9 in aneurysmal walls was also increased by methionine treatment. CONCLUSION: Hyperhomocysteinemia accelerates cerebral aneurysm formation,potentially through differential effects on expression of molecules critical for vascular wall modeling in a rat model. |
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Authors:
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Yong Xu; Jing-Fei Dong; Jian-Ning Zhang |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-4 |
Journal Detail:
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Title: Neuroscience letters Volume: - ISSN: 1872-7972 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Ireland Ltd. |
Affiliation:
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Department of Neurosurgery,Tianjin Medical University General Hospital; Tianjin Neurological Institute; Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System,Ministry of Education; Tianjin Key Laboratory of Injuries,Variations and Regeneration of Nervous System,Tianjin,P.R.300052 China. |
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