| Methiocarb-induced oxidative damage following subacute exposure and the protective effects of vitamin E and taurine in rats. | |
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MedLine Citation:
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PMID: 19394395 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Methiocarb, is used worldwide in agriculture and health programs. Besides its advantages in the agriculture, it causes several toxic effects. In this study, we aimed to investigate subacute effects of methiocarb on lipid peroxidation, reduced glutathione (GSH), antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and glutathione reductase (GSH-Rd) and histopathological changes in rat tissues. Moreover, we examined the possible protective effects of vitamin E and taurine on methiocarb-induced oxidative damage in rat tissues. Rats were randomly divided into six groups as follows; I-control group; II-methiocarb group; III-vitamin E group; IV-vitamin E+methiocarb group; V-taurine group and VI-taurine+methiocarb group. Methiocarb significantly increased lipid peroxidation in liver and kidney when compared to control groups. Levels of GSH and activities of SOD, CAT and GSH-Px were found to be decreased, while GSH-Rd remained unchanged in rat liver and kidney treated with methiocarb. Pretreatment of vitamin E and taurine resulted in a significant decrease on lipid peroxidation, alleviating effects on GSH and antioxidant enzymes. The degenerative histological changes were less in liver than kidney of rats treated with methiocarb. Pretreatment of vitamin E and taurine showed a protective effect on the histological changes in kidney comparing to the liver of rats treated with methiocarb. |
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Authors:
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Sibel Ozden; Betul Catalgol; Selda Gezginci-Oktayoglu; Pelin Arda-Pirincci; Sehnaz Bolkent; Buket Alpertunga |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-04-24 |
Journal Detail:
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Title: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Volume: 47 ISSN: 1873-6351 ISO Abbreviation: Food Chem. Toxicol. Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-10 Completed Date: 2009-08-28 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8207483 Medline TA: Food Chem Toxicol Country: England |
Other Details:
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Languages: eng Pagination: 1676-84 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Istanbul University, 34116 Beyazit, Istanbul, Turkey. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / metabolism, pharmacology* Drug-Induced Liver Injury / enzymology, pathology, prevention & control Glutathione / metabolism Insecticides / antagonists & inhibitors*, toxicity* Kidney Diseases / chemically induced, pathology, prevention & control Lipid Peroxidation / drug effects Male Methiocarb / antagonists & inhibitors*, toxicity* Oxidative Stress / drug effects* Rats Rats, Wistar Taurine / pharmacology* Vitamin E / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Insecticides; 107-35-7/Taurine; 1406-18-4/Vitamin E; 2032-65-7/Methiocarb; 70-18-8/Glutathione |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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