| Methicillin-resistant Staphylococcus aureus colonization and its association with infection among infants hospitalized in neonatal intensive care units. | |
| | |
MedLine Citation:
|
PMID: 16882797 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: We conducted this study to assess the rate of methicillin-resistant Staphylococcus aureus colonization and its association with infection among infants hospitalized in methicillin-resistant S aureus-endemic NICUs. METHODS: Between March 2003 and February 2004, surveillance culture specimens from the nares, postauricular areas, axillae, and umbilicus of infants admitted to the NICUs at a children's hospital in Taiwan were obtained weekly for the detection of methicillin-resistant S aureus. All colonized and clinical isolates from each study infant with methicillin-resistant S aureus infection were genotyped with pulsed-field gel electrophoresis, with Sma1 digestion, and compared. RESULTS: A total of 783 infants were included in this study. Methicillin-resistant S aureus colonization was detected for 323 infants during their NICU stays, with detection with the first 2 samples for 89%. Nares and umbilicus were the 2 most common sites of initial colonization. Methicillin-resistant S aureus colonization was associated significantly with premature birth (< or = 28 weeks) and low birth weight (< or = 1500 g), and infants with colonization had a significantly higher rate of methicillin-resistant S aureus infection, compared with those without colonization (26% vs 2%). Methicillin-resistant S aureus colonization was noted for 84 of 92 infants with methicillin-resistant S aureus infections. Of the 68 episodes with previous colonization and isolates available for genotyping analysis, colonized and clinical isolates were indistinguishable in 63 episodes, highly related in 2 episodes, and distinct in 3 episodes. CONCLUSIONS: More than 40% of the hospitalized infants were colonized with methicillin-resistant S aureus during their stay in methicillin-resistant S aureus-endemic NICUs; this was associated significantly with methicillin-resistant S aureus infection. Most infants with methicillin-resistant S aureus infections had previous colonization with an indistinguishable strain. |
| | |
Authors:
|
Yhu-Chering Huang; Yi-Hong Chou; Lin-Hui Su; Rey-In Lien; Tzou-Yien Lin |
Related Documents
:
|
348607 - Risk factors in early-onset neonatal group b streptococcal infections. 16613997 - Early prediction of sepsis-induced disseminated intravascular coagulation with interleu... 1853167 - Spread of klebsiella in a neonatal ward. 20930597 - Multiple ecthyma gangrenosum in a healthy infant with community-acquired pseudomonas ae... 8231577 - Effects of acid on the larynx of the maturing rabbit and their possible significance to... 15121927 - To tap or not to tap: high likelihood of meningitis without sepsis among very low birth... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Pediatrics Volume: 118 ISSN: 1098-4275 ISO Abbreviation: Pediatrics Publication Date: 2006 Aug |
Date Detail:
|
Created Date: 2006-08-02 Completed Date: 2006-09-11 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: United States |
Other Details:
|
Languages: eng Pagination: 469-74 Citation Subset: AIM; IM |
Affiliation:
|
Division of Pediatric Infectious Diseases, Chang Gung Children's Hospital, 5 Fu-Shin St, Kweishan, Taoyuan, Taiwan. ychuang@adm.cgmh.org.tw |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Axilla
/
microbiology Bacteremia / epidemiology, microbiology Bacterial Typing Techniques Birth Weight Carrier State / epidemiology*, microbiology Cross Infection / epidemiology*, microbiology DNA, Bacterial / analysis Ear, External / microbiology Female Gestational Age Hospitals, Pediatric / statistics & numerical data Hospitals, University / statistics & numerical data Humans Infant Infant, Newborn Infant, Premature Infant, Premature, Diseases / epidemiology*, microbiology Intensive Care Units, Neonatal / statistics & numerical data* Male Methicillin Resistance* Nose / microbiology Patient Isolation Skin / microbiology* Sputum / microbiology Staphylococcal Infections / epidemiology*, microbiology Staphylococcus aureus / drug effects, genetics, isolation & purification* Taiwan / epidemiology Umbilicus / microbiology |
| Chemical | |
Reg. No./Substance:
|
0/DNA, Bacterial |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: What pediatricians should know about child-related malpractice payments in the United States.
Next Document: Cerebral palsy among children born after in vitro fertilization: the role of preterm delivery--a pop...