Document Detail


Methicillin-resistant Staphylococcus aureus colonization and its association with infection among infants hospitalized in neonatal intensive care units.
MedLine Citation:
PMID:  16882797     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: We conducted this study to assess the rate of methicillin-resistant Staphylococcus aureus colonization and its association with infection among infants hospitalized in methicillin-resistant S aureus-endemic NICUs. METHODS: Between March 2003 and February 2004, surveillance culture specimens from the nares, postauricular areas, axillae, and umbilicus of infants admitted to the NICUs at a children's hospital in Taiwan were obtained weekly for the detection of methicillin-resistant S aureus. All colonized and clinical isolates from each study infant with methicillin-resistant S aureus infection were genotyped with pulsed-field gel electrophoresis, with Sma1 digestion, and compared. RESULTS: A total of 783 infants were included in this study. Methicillin-resistant S aureus colonization was detected for 323 infants during their NICU stays, with detection with the first 2 samples for 89%. Nares and umbilicus were the 2 most common sites of initial colonization. Methicillin-resistant S aureus colonization was associated significantly with premature birth (< or = 28 weeks) and low birth weight (< or = 1500 g), and infants with colonization had a significantly higher rate of methicillin-resistant S aureus infection, compared with those without colonization (26% vs 2%). Methicillin-resistant S aureus colonization was noted for 84 of 92 infants with methicillin-resistant S aureus infections. Of the 68 episodes with previous colonization and isolates available for genotyping analysis, colonized and clinical isolates were indistinguishable in 63 episodes, highly related in 2 episodes, and distinct in 3 episodes. CONCLUSIONS: More than 40% of the hospitalized infants were colonized with methicillin-resistant S aureus during their stay in methicillin-resistant S aureus-endemic NICUs; this was associated significantly with methicillin-resistant S aureus infection. Most infants with methicillin-resistant S aureus infections had previous colonization with an indistinguishable strain.
Authors:
Yhu-Chering Huang; Yi-Hong Chou; Lin-Hui Su; Rey-In Lien; Tzou-Yien Lin
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatrics     Volume:  118     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-02     Completed Date:  2006-09-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  469-74     Citation Subset:  AIM; IM    
Affiliation:
Division of Pediatric Infectious Diseases, Chang Gung Children's Hospital, 5 Fu-Shin St, Kweishan, Taoyuan, Taiwan. ychuang@adm.cgmh.org.tw
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MeSH Terms
Descriptor/Qualifier:
Axilla / microbiology
Bacteremia / epidemiology,  microbiology
Bacterial Typing Techniques
Birth Weight
Carrier State / epidemiology*,  microbiology
Cross Infection / epidemiology*,  microbiology
DNA, Bacterial / analysis
Ear, External / microbiology
Female
Gestational Age
Hospitals, Pediatric / statistics & numerical data
Hospitals, University / statistics & numerical data
Humans
Infant
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / epidemiology*,  microbiology
Intensive Care Units, Neonatal / statistics & numerical data*
Male
Methicillin Resistance*
Nose / microbiology
Patient Isolation
Skin / microbiology*
Sputum / microbiology
Staphylococcal Infections / epidemiology*,  microbiology
Staphylococcus aureus / drug effects,  genetics,  isolation & purification*
Taiwan / epidemiology
Umbilicus / microbiology
Chemical
Reg. No./Substance:
0/DNA, Bacterial

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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