|Methicillin-resistant Staphylococcus aureus colonization and its association with infection among infants hospitalized in neonatal intensive care units.|
|PMID: 16882797 Owner: NLM Status: MEDLINE|
|OBJECTIVES: We conducted this study to assess the rate of methicillin-resistant Staphylococcus aureus colonization and its association with infection among infants hospitalized in methicillin-resistant S aureus-endemic NICUs. METHODS: Between March 2003 and February 2004, surveillance culture specimens from the nares, postauricular areas, axillae, and umbilicus of infants admitted to the NICUs at a children's hospital in Taiwan were obtained weekly for the detection of methicillin-resistant S aureus. All colonized and clinical isolates from each study infant with methicillin-resistant S aureus infection were genotyped with pulsed-field gel electrophoresis, with Sma1 digestion, and compared. RESULTS: A total of 783 infants were included in this study. Methicillin-resistant S aureus colonization was detected for 323 infants during their NICU stays, with detection with the first 2 samples for 89%. Nares and umbilicus were the 2 most common sites of initial colonization. Methicillin-resistant S aureus colonization was associated significantly with premature birth (< or = 28 weeks) and low birth weight (< or = 1500 g), and infants with colonization had a significantly higher rate of methicillin-resistant S aureus infection, compared with those without colonization (26% vs 2%). Methicillin-resistant S aureus colonization was noted for 84 of 92 infants with methicillin-resistant S aureus infections. Of the 68 episodes with previous colonization and isolates available for genotyping analysis, colonized and clinical isolates were indistinguishable in 63 episodes, highly related in 2 episodes, and distinct in 3 episodes. CONCLUSIONS: More than 40% of the hospitalized infants were colonized with methicillin-resistant S aureus during their stay in methicillin-resistant S aureus-endemic NICUs; this was associated significantly with methicillin-resistant S aureus infection. Most infants with methicillin-resistant S aureus infections had previous colonization with an indistinguishable strain.|
|Yhu-Chering Huang; Yi-Hong Chou; Lin-Hui Su; Rey-In Lien; Tzou-Yien Lin|
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|Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't|
|Title: Pediatrics Volume: 118 ISSN: 1098-4275 ISO Abbreviation: Pediatrics Publication Date: 2006 Aug|
|Created Date: 2006-08-02 Completed Date: 2006-09-11 Revised Date: 2006-11-15|
Medline Journal Info:
|Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: United States|
|Languages: eng Pagination: 469-74 Citation Subset: AIM; IM|
|Division of Pediatric Infectious Diseases, Chang Gung Children's Hospital, 5 Fu-Shin St, Kweishan, Taoyuan, Taiwan. firstname.lastname@example.org|
|APA/MLA Format Download EndNote Download BibTex|
Bacteremia / epidemiology, microbiology
Bacterial Typing Techniques
Carrier State / epidemiology*, microbiology
Cross Infection / epidemiology*, microbiology
DNA, Bacterial / analysis
Ear, External / microbiology
Hospitals, Pediatric / statistics & numerical data
Hospitals, University / statistics & numerical data
Infant, Premature, Diseases / epidemiology*, microbiology
Intensive Care Units, Neonatal / statistics & numerical data*
Nose / microbiology
Skin / microbiology*
Sputum / microbiology
Staphylococcal Infections / epidemiology*, microbiology
Staphylococcus aureus / drug effects, genetics, isolation & purification*
Taiwan / epidemiology
Umbilicus / microbiology
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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