Document Detail


Methicillin-resistant Staphylococcus aureus ST80-IV clone in children from Jordan.
MedLine Citation:
PMID:  22520226     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of infections that are becoming increasingly difficult to combat because of emerging resistance. In this study, 103 S. aureus, 41 MRSA and 62 methicillin-sensitive Staphylococcus aureus isolates, were collected from children in Jordan. Genotyping based on spa and multilocus sequence typing (MLST) revealed 48 different spa types and identified distinct allelic profiles or STs, with the majority belonging to ST80. Pulsed-field gel electrophoresis (PFGE) of 15 different spa types revealed 8 different PFGE types, while SCCmec showed the predominance (53%) of subtype IV. Clustering SCCmec along with MLST revealed that ST80-MRSA-IV was the dominant type. Results obtained suggest that a significant amount of clonal spread is occurring in Jordan. The mechanism of spread of the ST80-IV clone is not known, and control measures are needed to reduce further spread of this or of other clones among children in Jordan.
Authors:
Wissam Khalil; Fuad Hashwa; Asem Shihabi; Sima Tokajian
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-18
Journal Detail:
Title:  Diagnostic microbiology and infectious disease     Volume:  -     ISSN:  1879-0070     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8305899     Medline TA:  Diagn Microbiol Infect Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Genomics and Proteomics Research Lab, Department of Biology, Lebanese American University, Byblos, Lebanon.
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