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Methicillin-resistant Staphylococcus aureus sequence type 239-III, Ohio, USA, 2007-2009.
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MedLine Citation:
PMID:  23018025     Owner:  NLM     Status:  MEDLINE    
Methicillin-resistant Staphylococcus aureus (MRSA) is a human pathogen that has diverse molecular heterogeneity. Most MRSA strains in the United States are pulsed-field gel electrophoresis USA100 sequence type (ST) 5 and USA300 ST8. Infections with MRSA ST239-III are common and found during health care-associated outbreaks. However, this strain has been rarely reported in the United States. As part of a study supported by the Prevention Epicenter Program of the Centers for Disease Control and Prevention (Atlanta, GA, USA), which evaluated transmission of MRSA among hospitals in Ohio, molecular typing identified 78 (6%) of 1,286 patients with MRSA ST239-III infections. Ninety-five percent (74/78) of these infections were health care associated, and 65% (51/78) of patients had histories of invasive device use. The crude case-fatality rate was 22% (17/78). Identification of these strains, which belong to a virulent clonal group, emphasizes the need for molecular surveillance.
Shu-Hua Wang; Yosef Khan; Lisa Hines; José R Mediavilla; Liangfen Zhang; Liang Chen; Armando Hoet; Tammy Bannerman; Preeti Pancholi; D Ashley Robinson; Barry N Kreiswirth; Kurt B Stevenson;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Emerging infectious diseases     Volume:  18     ISSN:  1080-6059     ISO Abbreviation:  Emerging Infect. Dis.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-28     Completed Date:  2013-02-19     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  9508155     Medline TA:  Emerg Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1557-65     Citation Subset:  IM    
Ohio State University Wexner Medical Center, Columbus, Ohio 43210, USA.
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MeSH Terms
Aged, 80 and over
Anti-Bacterial Agents / pharmacology
Bacterial Typing Techniques
Catheterization / adverse effects
Cross Infection / epidemiology*,  microbiology
Methicillin-Resistant Staphylococcus aureus / classification,  drug effects,  genetics*
Microbial Sensitivity Tests
Middle Aged
Molecular Typing
Ohio / epidemiology
Renal Dialysis / adverse effects
Respiration, Artificial / adverse effects
Staphylococcal Infections / epidemiology*,  microbiology
Young Adult
Grant Support
Reg. No./Substance:
0/Anti-Bacterial Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): Emerg Infect Dis
Journal ID (iso-abbrev): Emerging Infect. Dis
Journal ID (publisher-id): EID
ISSN: 1080-6040
ISSN: 1080-6059
Publisher: Centers for Disease Control and Prevention
Article Information
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Print publication date: Month: 10 Year: 2012
Volume: 18 Issue: 10
First Page: 1557 Last Page: 1565
PubMed Id: 23018025
ID: 3471631
Publisher Id: 12-0468
DOI: 10.3201/eid1810.120468

Methicillin-Resistant Staphylococcus aureus Sequence Type 239-III, Ohio, USA, 2007–20091 Alternate Title:MRSA Sequence Type 239-III, Ohio, USA, 2007–2009
Shu-Hua Wang
Yosef Khan
Lisa Hines
José R. Mediavilla
Liangfen Zhang
Liang Chen
Armando Hoet
Tammy Bannerman
Preeti Pancholi
D. Ashley Robinson
Barry N. Kreiswirth
Kurt B. Stevenson
for the Prevention Epicenter Program of the Centers for Disease Control and Prevention
The Ohio State University Wexner Medical Center, Columbus, Ohio, USA (S.H. Wang, Y. Khan, L. Hines, A. Hoet, P. Pancholi, K.B. Stevenson);
University of Medicine and Dentistry of New Jersey, Newark, New Jersey, USA (J.R. Mediavilla, L. Chen, B.N. Kreiswirth);
University of Mississippi Medical Center, Jackson, Mississippi, USA (L. Zhang, D.A. Robinson);
and The Ohio Department of Health Laboratories, Reynoldsburg, Ohio, USA (T. Bannerman)

Medscape CME Activity

Medscape, LLC is pleased to provide online continuing medical education (CME) for this journal article, allowing clinicians the opportunity to earn CME credit.

This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education through the joint sponsorship of Medscape, LLC and Emerging Infectious Diseases. Medscape, LLC is accredited by the ACCME to provide continuing medical education for physicians.

Medscape, LLC designates this Journal-based CME activity for a maximum of 1 AMA PRA Category 1 Credit(s)TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

All other clinicians completing this activity will be issued a certificate of participation. To participate in this journal CME activity: (1) review the learning objectives and author disclosures; (2) study the education content; (3) take the post-test with a 70% minimum passing score and complete the evaluation at; (4) view/print certificate.

Release date: September 20, 2012; Expiration date: September 20, 2013

Learning Objectives

Upon completion of this activity, participants will be able to:

  • Distinguish the most common strains of methicillin-resistant Staphylococcus aureus (MRSA) in the United States
  • Assess the clinical characteristics of infection with MRSA-ST239-III
  • Analyze the treatment and prognosis of MRSA-ST239-III infection
  • Evaluate molecular characteristics of MRSA-ST239-III.

CME Editor

Thomas J. Gryczan, MS, Technical Writer/Editor, Emerging Infectious Diseases. Disclosure: Thomas J. Gryczan, MS, has disclosed no relevant financial relationships.

CME Author

Charles P. Vega, MD, Health Sciences Clinical Professor; Residency Director, Department of Family Medicine, University of California, Irvine. Disclosure: Charles P. Vega, MD, has disclosed no relevant financial relationships.


Disclosures: Shu-Hua Wang, MD, MPH; Yosef Khan, MBBS, PhD; Jose R. Mediavilla, MBS, MPH; Liangfen Zhang, MD, PhD; Liang Chen, PhD; Armando Hoet, PhD; Tammy Bannerman; D. Ashley Robinson, PhD; Barry N. Kreiswirth, PhD; and Kurt B. Stevenson, MD, MPH, have disclosed no relevant financial relationships. Lisa Hines, RN, CIC,has disclosed the following relevant financial relationships: owns stock, stock options, or bonds from Kimberly-Clark Corp., General Electric Co., Medtronic Inc., Stryker Corp., TEVA Pharmaceutical Industries. Preeti Pancholi, PhD, has disclosed the following relevant financial relationships: served as an advisor or consultant for Abbott; served as a speaker or a member of a speakers bureau for Abbott, Nanosphere; received grants for clinical research from Cepheid, Abbott, Quidel, Qiagen, Nanosphere.


Suggested citation for this article: Wang S-H, Khan Y, Hines L, Mediavilla JR, Zhang L, Chen L, et al. Methicillin-resistant Staphylococcus aureus sequence type 239-III, Ohio, USA, 2007–2009. Emerg Infect Dis [Internet]. 2012 Oct [date cited].

1Presented in part at the 48th Annual Meeting of the Infectious Diseases Society of America, Vancouver, British Columbia, Canada, October 21–24, 2010.

Article Categories:
  • CME
Article Categories:
  • Research
Article Categories:
  • Research

Keywords: Keywords: Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, MRSA, MRSA ST239-III, bacteria, sequence type, virulent clones, Brazilian clone, Portuguese clone, Ohio, United States.

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