Document Detail

Methemoglobinemia from overdose of phenazopyridine hydrochloride.
MedLine Citation:
PMID:  7362105     Owner:  NLM     Status:  MEDLINE    
A case of severe methemoglobinemia and hemolytic anemia following ingestion of 5.6 gm of phenazopyridine with suicidal intent by a 16-year-old woman was successfully treated with intravenous methylene blue. Methemoglobinemia was suspected in this patient because of her intense central cyanosis, chocolate-colored blood, and minimal dyspnea. The patient's peripheral blood smear exhibited "bite cells." To the best of our knowledge, this is only the third such case reported in the literature. The pathophysiology, diagnosis, and therapy are reviewed.
R C Zimmerman; E D Green; W H Ghurabi; D P Colohan
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Annals of emergency medicine     Volume:  9     ISSN:  0196-0644     ISO Abbreviation:  Ann Emerg Med     Publication Date:  1980 Mar 
Date Detail:
Created Date:  1980-05-14     Completed Date:  1980-05-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8002646     Medline TA:  Ann Emerg Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  147-9     Citation Subset:  IM    
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MeSH Terms
Aminopyridines / poisoning*
Methemoglobin / analysis
Methemoglobinemia / chemically induced*,  drug therapy
Methylene Blue / administration & dosage*
Phenazopyridine / poisoning*
Suicide, Attempted
Reg. No./Substance:
0/Aminopyridines; 61-73-4/Methylene Blue; 9008-37-1/Methemoglobin; 94-78-0/Phenazopyridine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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