| Methemoglobinemia and dapsone levels in patients with leprosy. | |
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MedLine Citation:
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PMID: 20835521 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this work was to determine the methemoglobinemia and correlate with dapsone levels in multibacillary leprosy patients under leprosy multi-drug therapy. Thirty patients with laboratory and clinical diagnosis of multibacillary leprosy were enrolled. Dapsone was analyzed by high performance liquid chromatography and methemoglobinemia by spectrophotometry. The mean dapsone concentrations in male was 1.42 g/mL and in female was 2.42 g/mL. The mean methemoglobin levels in male was 3.09 µg/mL; 191%, and in female was 2.84 ± 1.67%. No correlations were seen between dapsone levels and methemoglobin in male and female patients. Our results demonstrated that the dosage of dapsone in leprosy treatment does not promote a significant methemoglobinemia. |
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Authors:
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Jose Luiz Fernandes Vieira; Juan Gonzalo Bardarez Riveira; Ana de Nazaré Silva Martins; Jorge Pereira da Silva; Claudio Guedes Salgado |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases Volume: 14 ISSN: 1678-4391 ISO Abbreviation: Braz J Infect Dis Publication Date: 2010 May-Jun |
Date Detail:
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Created Date: 2010-09-13 Completed Date: 2010-12-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9812937 Medline TA: Braz J Infect Dis Country: Brazil |
Other Details:
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Languages: eng Pagination: 319-21 Citation Subset: IM |
Affiliation:
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Pharmacy School, Universidade Federal do Pará, Belém, PA, Brazil. jvieira@ufpa.br |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Chromatography, High Pressure Liquid Clofazimine / administration & dosage Dapsone / administration & dosage, adverse effects, blood* Female Humans Leprostatic Agents / administration & dosage*, adverse effects Leprosy, Multibacillary / blood, drug therapy* Male Methemoglobinemia / chemically induced, diagnosis* Rifampin / administration & dosage Spectrophotometry Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Leprostatic Agents; 13292-46-1/Rifampin; 2030-63-9/Clofazimine; 80-08-0/Dapsone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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