Document Detail

Methemoglobinemia and dapsone levels in patients with leprosy.
MedLine Citation:
PMID:  20835521     Owner:  NLM     Status:  MEDLINE    
The objective of this work was to determine the methemoglobinemia and correlate with dapsone levels in multibacillary leprosy patients under leprosy multi-drug therapy. Thirty patients with laboratory and clinical diagnosis of multibacillary leprosy were enrolled. Dapsone was analyzed by high performance liquid chromatography and methemoglobinemia by spectrophotometry. The mean dapsone concentrations in male was 1.42 g/mL and in female was 2.42 g/mL. The mean methemoglobin levels in male was 3.09 µg/mL; 191%, and in female was 2.84 ± 1.67%. No correlations were seen between dapsone levels and methemoglobin in male and female patients. Our results demonstrated that the dosage of dapsone in leprosy treatment does not promote a significant methemoglobinemia.
Jose Luiz Fernandes Vieira; Juan Gonzalo Bardarez Riveira; Ana de Nazaré Silva Martins; Jorge Pereira da Silva; Claudio Guedes Salgado
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases     Volume:  14     ISSN:  1678-4391     ISO Abbreviation:  Braz J Infect Dis     Publication Date:    2010 May-Jun
Date Detail:
Created Date:  2010-09-13     Completed Date:  2010-12-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9812937     Medline TA:  Braz J Infect Dis     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  319-21     Citation Subset:  IM    
Pharmacy School, Universidade Federal do Pará, Belém, PA, Brazil.
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MeSH Terms
Chromatography, High Pressure Liquid
Clofazimine / administration & dosage
Dapsone / administration & dosage,  adverse effects,  blood*
Leprostatic Agents / administration & dosage*,  adverse effects
Leprosy, Multibacillary / blood,  drug therapy*
Methemoglobinemia / chemically induced,  diagnosis*
Rifampin / administration & dosage
Young Adult
Reg. No./Substance:
0/Leprostatic Agents; 13292-46-1/Rifampin; 2030-63-9/Clofazimine; 80-08-0/Dapsone

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