Document Detail


Methemoglobinemia associated with loxoscelism.
MedLine Citation:
PMID:  2259827     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In twenty five patients who presented the cutaneous form of loxoscelism, serum haptoglobin and lactic dehydrogenase, erythrocyte glucose-6-phosphate dehydrogenase, glutathione reductase, glutathione peroxidase, methemoglobin, bilirubin and reticulocytes were investigated after bite. No hemolysis was detected but an increase in methemoglobin was found in 54% of the cases; in 7% it was between 1.1% and 2%, in 27% it ranged from 2.1% to 4%, and in 20% from 4.1% to 8%. Blood samples of a normal, blood group 0 individual and of a patient who exhibited methemoglobinemia after Loxosceles bite were incubated separately with antisera against Loxosceles gaucho, Crotalus terrificus, Bothrops jararaca, with Loxosceles gaucho venom and 0.3% phenol. No methemoglobin was found after 1, 4, 8 and 15 days in both sets of samples. At the 25th day all the samples, including the controls, exhibited similar methemoglobin reductase decrease. The data suggest that the methemoglobinemia which occurs in 50% of the patients probably arises from in vivo venom metabolism, inasmuch as the crude venom does not induce methemoglobinemia.
Authors:
O C Barretto; D M De Cillo; K Nonoyama; L C Antonio; P Morena; J L Cardoso
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Revista do Instituto de Medicina Tropical de São Paulo     Volume:  32     ISSN:  0036-4665     ISO Abbreviation:  Rev. Inst. Med. Trop. Sao Paulo     Publication Date:    1990 Jan-Feb
Date Detail:
Created Date:  1991-01-28     Completed Date:  1991-01-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7507484     Medline TA:  Rev Inst Med Trop Sao Paulo     Country:  BRAZIL    
Other Details:
Languages:  eng     Pagination:  1-5     Citation Subset:  IM    
Affiliation:
Laboratório de Pesquisas Hemotológicas-LIM/31 Faculdade de Medicina da Universidade de São Paulo, Brasil.
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MeSH Terms
Descriptor/Qualifier:
Arachnidism / blood*,  complications
Cytochrome-B(5) Reductase / metabolism
Erythrocytes / enzymology
Humans
Methemoglobinemia / blood*,  etiology
Chemical
Reg. No./Substance:
EC 1.6.2.2/Cytochrome-B(5) Reductase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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