Document Detail

Methemoglobin to cumulative nitric oxide ratio and response to inhaled nitric oxide in PPHN.
MedLine Citation:
PMID:  19554014     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: One-third of infants with persistent pulmonary hypertension of the newborn (PPHN) do not respond to inhaled nitric oxide (iNO). If iNO is not delivered to the pulmonary vasculature because of parenchymal lung disease, it cannot interact with hemoglobin to form methemoglobin (MHb). OBJECTIVE: To study the correlation between oxygenation response to iNO in infants with PPHN secondary to parenchymal lung disease and initial MHb% to cumulative NO exposure (ppm x hours) ratio (MHb/SigmaNO). STUDY DESIGN: Retrospective chart review of neonates with PPHN secondary to parenchymal lung disease treated with iNO comparing non-responders (PaO(2)/FiO(2) ratio<10 change with iNO) with responders (>or=10 change). RESULT: Non-responders (n=16) had a PaO(2)/F(iO2) of 83+/-48 (mean+/-s.d.) and decreased to 74+/-44 after iNO. PaO(2)/FiO(2) increased from 70+/-48 to 151+/-63 with iNO among responders (n=36). The MHb/SigmaNO ratio was low (0.024+/-0.012) among non-responders compared with responders (0.07+/-0.053, P<0.005). CONCLUSION: Inadequate oxygenation response to iNO is associated with lower MHb/SigmaNO, suggesting suboptimal delivery of iNO to the pulmonary vasculature.
M J Pabalan; S P Nayak; R M Ryan; V H Kumar; S Lakshminrusimha
Related Documents :
16493434 - Risk factors and clinical outcomes of pulmonary interstitial emphysema in extremely low...
1432554 - Oro-naso-pharyngeal suction at birth: effects on respiratory adaptation of normal term ...
15774824 - Endothelin-a receptor blockade prevents and partially reverses neonatal hypoxic pulmona...
16188814 - Nitric oxide in neonatal transposition of the great arteries.
7158644 - Omphalocele and multiple severe congenital anomalies associated with osteodysplasty (me...
7146394 - Ultrasonic detection of complications following umbilical arterial catheterization in t...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-06-25
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  29     ISSN:  1476-5543     ISO Abbreviation:  J Perinatol     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-28     Completed Date:  2010-01-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  698-701     Citation Subset:  IM    
Department of Pediatrics, Division of Neonatology, University at Buffalo, Women and Children's Hospital of Buffalo, Buffalo, NY 14222, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Administration, Inhalation
Blood Gas Analysis
Case-Control Studies
Dose-Response Relationship, Drug
Drug Monitoring
Infant, Newborn
Meconium Aspiration Syndrome / complications
Methemoglobin / analysis*,  metabolism
Nitric Oxide / administration & dosage*,  blood*
Persistent Fetal Circulation Syndrome / complications,  drug therapy*
Pneumonia, Aspiration / complications
Respiratory Distress Syndrome, Newborn / complications
Retrospective Studies
Treatment Failure
Vasodilator Agents / administration & dosage*,  blood*
Reg. No./Substance:
0/Vasodilator Agents; 10102-43-9/Nitric Oxide; 9008-37-1/Methemoglobin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Chest compression and/or epinephrine at birth for preterm infants <32 weeks gestational age: matched...
Next Document:  Organism-specific platelet response and factors affecting survival in thrombocytopenic very low birt...