| Methanol toxicity. Agency for Toxic Substances and Disease Registry. | |
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MedLine Citation:
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PMID: 8418579 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Methanol is used in a variety of commercial and consumer products. Increased use of methanol as a motor fuel may lead to higher ambient air levels and a greater potential for ingestion from siphoning accidents. Methanol toxicity initially is not characterized by severe toxic manifestations. Pathophysiologically, methanol toxicity represents a classic example of "lethal synthesis," in which toxic metabolites can cause fatality after a characteristic latent period. Methanol is well absorbed following inhalation, ingestion or cutaneous exposure. It is oxidized in the liver to formaldehyde, then to formic acid, which contributes to the profound metabolic acidosis occurring in acute methanol poisoning. The metabolic products of methanol can produce a syndrome of delayed-onset acidosis, obtundation, visual disturbance and death. Intravenous sodium bicarbonate therapy should be considered if the patient's blood pH is below 7.2. Symptoms and history determine whether intravenous ethanol therapy and hemodialysis should be instituted. |
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Authors:
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: American family physician Volume: 47 ISSN: 0002-838X ISO Abbreviation: Am Fam Physician Publication Date: 1993 Jan |
Date Detail:
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Created Date: 1993-02-04 Completed Date: 1993-02-04 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 1272646 Medline TA: Am Fam Physician Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 163-71 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Aged Chronic Disease Clinical Protocols Environmental Exposure Ethanol / therapeutic use Family Practice / methods Folic Acid / therapeutic use Humans Male Methanol / poisoning* Poisoning / diagnosis, epidemiology*, therapy Pyrazoles / therapeutic use Renal Dialysis Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Pyrazoles; 59-30-3/Folic Acid; 64-17-5/Ethanol; 67-56-1/Methanol; 7554-65-6/fomepizole |
| Comments/Corrections | |
Comment In:
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Am Fam Physician. 1993 Oct;48(5):731
[PMID:
8213402
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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