| Methanol intoxication-induced nigrostriatal dysfunction detected using 6-[18F]fluoro-L-dopa PET. | |
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MedLine Citation:
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PMID: 18482768 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ingestion of windshield washer liquid resulted with an acute severe methanol intoxication in a 49-year old man. He developed optic atrophy with blindness, and an extrapyramidal syndrome. Putaminal injury and hyperintensity in the subcortical white matter was seen in a brain MRI. PET scanning with 6-[18F]fluoro-L-dopa confirmed symmetrical impaired presynaptic dopaminergic activity in the striatum, indicative of functional impairment of dopaminergic nigrostriatal neurons. The striatal uptake was more markedly impaired in the putamina (40% of controls) than in the caudate nuclei (60% of controls). To our knowledge, this is the first report of an 18F-dopa PET scanning result in a case of an acute methanol poisoning. |
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Authors:
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Laura Airas; Teemu Paavilainen; Reijo J Marttila; Juha Rinne |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-04-11 |
Journal Detail:
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Title: Neurotoxicology Volume: 29 ISSN: 0161-813X ISO Abbreviation: Neurotoxicology Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-07-08 Completed Date: 2008-11-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7905589 Medline TA: Neurotoxicology Country: Netherlands |
Other Details:
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Languages: eng Pagination: 671-4 Citation Subset: IM |
Affiliation:
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Department of Neurology, University of Turku, Turku, Finland. laura.airas@utu.fi |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Brain Diseases
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etiology*,
pathology,
radionuclide imaging Corpus Striatum / pathology, radionuclide imaging* Fluorodeoxyglucose F18 / diagnostic use Humans Levodopa / diagnostic use Male Methanol / toxicity* Middle Aged Poisoning / complications* Positron-Emission Tomography / methods Substantia Nigra / pathology, radionuclide imaging* |
| Chemical | |
Reg. No./Substance:
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0/Levodopa; 63503-12-8/Fluorodeoxyglucose F18; 67-56-1/Methanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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