Document Detail

Methamphetamine use: A comprehensive review of molecular, preclinical and clinical findings.
MedLine Citation:
PMID:  23273775     Owner:  NLM     Status:  Publisher    
Methamphetamine (MA) is a highly addictive psychostimulant drug that principally affects the monoamine neurotransmitter systems of the brain and results in feelings of alertness, increased energy and euphoria. The drug is particularly popular with young adults, due to its wide availability, relatively low cost, and long duration of psychoactive effects. Extended use of MA is associated with many health problems that are not limited to the central nervous system, and contribute to increased morbidity and mortality in drug users. Numerous studies, using complementary techniques, have provided evidence that chronic MA use is associated with substantial neurotoxicity and cognitive impairment. These pathological effects of the drug, combined with the addictive properties of MA, contribute to a spectrum of psychosocial issues that include medical and legal problems, at-risk behaviors and high societal costs, such as public health consequences, loss of family support and housing instability. Treatment options include pharmacological, psychological or combination therapies. The present review summarizes the key findings in the literature spanning from molecular through to clinical effects.
William J Panenka; Ric M Procyshyn; Tania Lecomte; G William Macewan; Sean W Flynn; William G Honer; Alasdair M Barr
Related Documents :
24410705 - Novel methods of targeted drug delivery: the potential of multifunctional nanoparticles.
11990585 - Determination of lomefloxacin, an antibacterial drug, in pharmaceutical preparations ba...
23895025 - Anticoagulation with rivaroxaban: covering a broad spectrum of thromboembolic disease.
15544525 - Can an apple a day keep the doctor away?
23421365 - Is avocado a real expulsive therapy in ureterolithiasis?
9598455 - First-time-in-humans safety and pharmacokinetics of wr 238605, a new antimalarial.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-26
Journal Detail:
Title:  Drug and alcohol dependence     Volume:  -     ISSN:  1879-0046     ISO Abbreviation:  Drug Alcohol Depend     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7513587     Medline TA:  Drug Alcohol Depend     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Department of Psychiatry, University of British Columbia, Vancouver, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Analysis of heart rate variability using fuzzy measure entropy.
Next Document:  Predictors of stimulant abuse treatment outcomes in severely mentally ill outpatients.