Document Detail

Methamphetamine-related sudden death with a concentration which was of a 'toxic level'.
MedLine Citation:
PMID:  16515879     Owner:  NLM     Status:  MEDLINE    
We reviewed 32 cases where a forensic autopsy detected methamphetamine in the blood, and all of these autopsies were performed at two institutes between 1991 and 2003. In accordance with several criteria, the blood concentration in 11 cases was classified as above the toxic level, and 10 of these cases were diagnosed as methamphetamine poisoning. In 20 cases (62.5% of total cases), the blood concentration was of a 'toxic level', and 10, 2 and 1 of these cases were diagnosed as methamphetamine poisoning, cardiomyopathy and intracerebral hemorrhage, respectively. Since it is unclear how the effects of methamphetamine may contribute to the death of an individual, a diagnosis of the exact cause of death is often difficult to make in cases where the blood concentration of methamphetamine was of a 'toxic level'. Therefore, a diagnosis has to be carefully made in consideration of the pathological findings, the pharmacological effects of methamphetamine and the process until death in such cases. Additionally, the mechanism of methamphetamine-related death needs to be more fully studied to enable an appropriate diagnosis to be made easily.
Hiromasa Inoue; Noriaki Ikeda; Keiko Kudo; Tomomi Ishida; Masaru Terada; Ryoji Matoba
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Publication Detail:
Type:  Journal Article     Date:  2006-03-03
Journal Detail:
Title:  Legal medicine (Tokyo, Japan)     Volume:  8     ISSN:  1344-6223     ISO Abbreviation:  Leg Med (Tokyo)     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-05-29     Completed Date:  2006-12-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100889186     Medline TA:  Leg Med (Tokyo)     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  150-5     Citation Subset:  IM    
Department of Forensic Pathology and Sciences, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan.
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MeSH Terms
Cause of Death
Central Nervous System Stimulants / administration & dosage,  blood*,  poisoning*
Death, Sudden / etiology*
Forensic Medicine
Japan / epidemiology
Methamphetamine / administration & dosage,  blood*,  poisoning*
Middle Aged
Poisoning / mortality
Reg. No./Substance:
0/Central Nervous System Stimulants; 537-46-2/Methamphetamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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