Document Detail

Methamphetamine-induced changes in activity and water intake during light and dark cycles in rats.
MedLine Citation:
PMID:  9829297     Owner:  NLM     Status:  MEDLINE    
1. The authors investigated the ambulatory activity and water intake of rats during each 12 hr light and dark cycle for one week following four s.c. injections of 4 or 8 mg/kg of methamphetamine (METH). 2. Administration of the higher METH dose caused an increase in activity during the dark cycle on days 1 through 6 with the maximal increase on day 3 while the increase in activity during the light cycle was observed only on day 1. 3. Water intake increased the first day after administration of both METH doses, but returned to baseline by day 3. 4. Administration of both METH doses induced hyperthermia and the 8 mg/kg dose produced depletions of striatal dopamine and striatal, hippocampal and hypothalamic serotonin on day 3 but only in hippocampal serotonin by day 7. 5. These results demonstrate that high doses of METH produce a long-lasting increase in activity during the dark cycle and a transient increase in water intake. The behavioral changes which occurred during the dark cycle appear to be related to the depletion of central dopamine and/or serotonin.
T Kita; M Takahashi; G C Wagner; K Kubo; T Nakashima
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Progress in neuro-psychopharmacology & biological psychiatry     Volume:  22     ISSN:  0278-5846     ISO Abbreviation:  Prog. Neuropsychopharmacol. Biol. Psychiatry     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1999-02-26     Completed Date:  1999-02-26     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8211617     Medline TA:  Prog Neuropsychopharmacol Biol Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1185-96     Citation Subset:  IM    
Department of Pharmacology, Nara Medical University, Japan.
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MeSH Terms
3,4-Dihydroxyphenylacetic Acid / metabolism
Biogenic Monoamines / metabolism*
Body Temperature / drug effects
Brain / drug effects,  metabolism*
Circadian Rhythm / drug effects*,  physiology
Corpus Striatum / metabolism
Dopamine / analogs & derivatives,  metabolism
Dose-Response Relationship, Drug
Drinking Behavior / drug effects*
Hippocampus / metabolism
Homovanillic Acid / metabolism
Hydroxyindoleacetic Acid / metabolism
Hypothalamus / metabolism
Methamphetamine / pharmacology*
Motor Activity / drug effects*
Rats, Wistar
Serotonin / metabolism
Reg. No./Substance:
0/Biogenic Monoamines; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 306-08-1/Homovanillic Acid; 50-67-9/Serotonin; 537-46-2/Methamphetamine; 54-16-0/Hydroxyindoleacetic Acid; 554-52-9/3-methoxytyramine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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