Document Detail

Methamphetamine abuse during pregnancy and its health impact on neonates born at Siriraj Hospital, Bangkok, Thailand.
MedLine Citation:
PMID:  15272773     Owner:  NLM     Status:  MEDLINE    
To ascertain the impact of intrauterine methamphetamine exposure on the overall health of newborn infants at Siriraj Hospital, Bangkok, Thailand, birth records of somatic growth parameters and neonatal withdrawal symptoms of 47 infants born to methamphetamine-abusing women during January 2001 to December 2001 were compared to 49 newborns whose mothers did not use methamphetamines during pregnancy. The data on somatic growth was analyzed using linear regression and multiple linear regression. The association between methamphetamine use and withdrawal symptoms was analyzed using the chi-square. Home visitation and maternal interview records were reviewed in order to assess for child-rearing attitude, and psychosocial parameters. Infants of methamphetamine-abusing mothers were found to have a significantly smaller gestational age-adjusted head circumference (regression coefficient = -1.458, p < 0.001) and birth weight (regression coefficient = -217.9, p < or = 0.001) measurements. Methamphetamine exposure was also associated with symptoms of agitation (5/47), vomiting (11/47) and tachypnea (12/47) when compared to the non-exposed group (p < 0r =0.001). Maternal interviews were conducted in 23 cases and showed that: 96% of the cases had inadequate prenatal care (<5 visits), 48% had at least one parent involved in prostitution, 39% of the mothers were unwilling to take their children home, and government or non-government support were provided in only 30% of the cases. In-utero methamphetamine exposure has been shown to adversely effect somatic growth of newborns and cause a variety of withdrawal-like symptoms. These infants are also psychosocially disadvantaged and are at greater risk for abuse and neglect.
Chulathida Chomchai; Natawadee Na Manorom; Pornchai Watanarungsan; Panitan Yossuck; Summon Chomchai
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Southeast Asian journal of tropical medicine and public health     Volume:  35     ISSN:  0125-1562     ISO Abbreviation:  Southeast Asian J. Trop. Med. Public Health     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-07-26     Completed Date:  2004-10-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0266303     Medline TA:  Southeast Asian J Trop Med Public Health     Country:  Thailand    
Other Details:
Languages:  eng     Pagination:  228-31     Citation Subset:  IM    
Division of Medical Toxicology and Ambulatory Pediatrics, Department of Pediatrics Faculty of Medicine at Siriraj Hospital, Mahidol University, Bangkok, Thailand.
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MeSH Terms
Amphetamine-Related Disorders / diagnosis,  epidemiology*
Birth Weight
Case-Control Studies
Fetal Growth Retardation / epidemiology,  ultrasonography
Follow-Up Studies
Hospitals, Urban
Infant, Newborn
Neonatal Abstinence Syndrome / diagnosis,  epidemiology*
Pregnancy Complications / diagnosis,  epidemiology*
Prenatal Exposure Delayed Effects*
Reference Values
Risk Assessment
Severity of Illness Index
Survival Rate
Thailand / epidemiology
Reg. No./Substance:

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