| Methamphetamine causes persistent immune dysregulation: a cross-species, translational report. | |
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MedLine Citation:
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PMID: 20953917 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Methamphetamine (MA) dependence causes serious cognitive impairments that can persist during abstinence and negatively affect recovery outcomes. Evidence suggests that immune factors, such as cytokines, chemokines, and cellular adhesion molecules, contribute to MA-induced immune dysfunction, neuronal injury, and persistent cognitive impairments, yet the role of MA-induced brain inflammation remains unclear. To address this question, we used a cross-species, translational approach. Thirty-two male C57BL/6J mice were administered MA (1 mg/kg) or saline subcutaneously for seven consecutive days. Mice were euthanized at 72 h or 3 weeks after the last drug dose, and blood and brain samples were collected. In addition, 20 adults in remission from MA dependence and 20 non-dependent controls completed neuropsychological assessments and a blood draw. Multiplex assays were used to measure cytokine, chemokine, and intercellular adhesion molecule (ICAM-1) expression in mouse and human samples. A number of significant MA-induced changes in neuroimmune factors were observed. Of particular interest were the chemokine monocyte chemoattractant protein 1 (MCP-1) and the cellular adhesion molecule ICAM-1, which were similarly increased in the plasma of MA exposed mice as well as humans. In human participants, MA-induced changes in the cytokine and chemokine milieu were accompanied by increased cognitive impairments. Mice showing MA-induced changes in peripheral immune molecule expression also had significant brain-region specific changes in pro-inflammatory cytokines, chemokines, and ICAM-1. This cross-species, translational study suggests that chronic CNS immune dysregulation may in part contribute to the longlasting neuropsychiatric consequences of MA dependence. |
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Authors:
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Jennifer M Loftis; Dongseok Choi; William Hoffman; Marilyn S Huckans |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-10-17 |
Journal Detail:
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Title: Neurotoxicity research Volume: 20 ISSN: 1476-3524 ISO Abbreviation: Neurotox Res Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-05-09 Completed Date: 2011-09-23 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 100929017 Medline TA: Neurotox Res Country: United States |
Other Details:
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Languages: eng Pagination: 59-68 Citation Subset: IM |
Affiliation:
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Research & Development Service, Portland VA Medical Center, 3710 SW U.S. Veterans Hospital Rd., R&D 16, Portland, OR 97239, USA. loftisj@ohsu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amphetamine-Related Disorders / blood, complications, metabolism* Animals Brain / metabolism Chemokine CCL2 / blood, metabolism Chemokines / blood, metabolism Cognition Disorders / chemically induced, complications, metabolism* Cytokines / blood, metabolism Disease Models, Animal Female Humans Immune System Diseases / chemically induced, complications, metabolism* Immunologic Factors / blood, metabolism* Intercellular Adhesion Molecule-1 / blood, metabolism Male Methamphetamine / adverse effects* Mice Mice, Inbred C57BL Neuropsychological Tests Random Allocation |
| Grant Support | |
ID/Acronym/Agency:
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P50 DA18165/DA/NIDA NIH HHS; RC1 DA028537-01/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Chemokine CCL2; 0/Chemokines; 0/Cytokines; 0/Immunologic Factors; 126547-89-5/Intercellular Adhesion Molecule-1; 537-46-2/Methamphetamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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