| Methaemoglobinaemia with G6PD deficiency; rare cause of persistently low saturations in neonates. | |
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MedLine Citation:
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PMID: 21418105 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We report a very rare case of methaemoglobinaemia associated with Glucose 6 Phosphate Dehydrogenase (G6PD) deficiency, complicating a respiratory illness in a preterm neonate. This neonate had consistently low saturation readings despite being ventilated at moderately high pressures in 100% oxygen. An arterial blood gas confirmed a high methaemoglobin level and a high pO2, inconsistent with the saturations. In addition, the bilirubin increased to exchange levels and was difficult to control with quadruple phototherapy. A double volume exchange transfusion was performed, which reduced both bilirubin and methaemoglobin. The pulse-oximetry then started to correlate well with pO2. G6PD deficiency was confirmed. Conclusion: Paediatricians should remember that methaemoglobinaemia is a rare but important cause of persistently low saturations and exchange transfusion is a reliable treatment for this condition. |
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Authors:
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Hannah Titheradge; Katie Nolan; Shanmugasundaram Sivakumar; Srinivas Bandi |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-19 |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992) Volume: - ISSN: 1651-2227 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Acta Paediatrica © 2011 Foundation Acta Paediatrica. |
Affiliation:
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Department of Paediatrics, Sandwell & West Birmingham NHS Hospitals Trust, United Kingdom. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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