| Methadone induction doses: are our current practices safe? | |
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MedLine Citation:
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PMID: 16956864 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To review the literature on methadone deaths and propose evidence-based dosing guidelines. METHODS: A literature search was conducted on overdose deaths during the induction phase. Data on methadone deaths from the Ontario coroner's office, as well as prescribing guidelines from different countries and jurisdictions, were reviewed. The information was collectively considered and, using the best available evidence, translated into safe dosing guidelines for methadone induction. RESULTS: A literature review found high death rates during the methadone induction period. Data from the Ontario coroner's office revealed that of deaths that were felt to be attributable to methadone overdose, the majority occurred in those who had consumed diverted methadone: of those deaths within a registered program, the majority occurred during the initial dosing phase. Despite high death rates during induction onto methadone treatment, many jurisdictions do not have prescribing guidelines that take this evidence into account. CONCLUSIONS: Safer prescribing guidelines are needed to reduce deaths during induction onto methadone treatment. Recommendations are made for safe methadone induction doses. |
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Authors:
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Anita Srivastava; Meldon Kahan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of addictive diseases Volume: 25 ISSN: 1055-0887 ISO Abbreviation: J Addict Dis Publication Date: 2006 |
Date Detail:
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Created Date: 2006-09-07 Completed Date: 2007-02-07 Revised Date: 2008-05-12 |
Medline Journal Info:
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Nlm Unique ID: 9107051 Medline TA: J Addict Dis Country: United States |
Other Details:
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Languages: eng Pagination: 5-13 Citation Subset: IM |
Affiliation:
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Centre for Addiction and Mental Health, Department of Family and Community Medicine, University of Toronto, ON, M5S 2S1, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Drug Administration Schedule Drug Interactions Drug Monitoring Drug Toxicity* Guidelines as Topic / standards* Heroin Dependence / mortality, rehabilitation* Humans Methadone / administration & dosage*, therapeutic use Narcotics / administration & dosage*, therapeutic use Patient Education as Topic Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Narcotics; 76-99-3/Methadone |
| Comments/Corrections | |
Comment In:
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J Addict Dis. 2006;25(3):1-3
[PMID:
16956863
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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