Document Detail

Methadone induced torsade de pointes in a patient receiving antiretroviral therapy.
MedLine Citation:
PMID:  18277734     Owner:  NLM     Status:  MEDLINE    
Adverse drug reactions account for approximately 5% of acute medical admissions. A 34-year-old male patient receiving antiretroviral therapy, methadone and flurazepam presented to the emergency room following collapse with associated loss of consciousness. Cardiac monitoring demonstrated marked Q-T prolongation followed by the cardiac arrhythmia, torsade de pointes. The patient made a full recovery following withdrawal of the antiretroviral therapy and a reduction in methadone dose. Methadone is a recognised cause of this potentially fatal cardiac arrhythmia which is more likely to occur when methadone metabolism is inhibited by drugs such as HIV tease inhibitors.
M Falconer; D Molloy; J Ingerhaug; M Barry
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Irish medical journal     Volume:  100     ISSN:  0332-3102     ISO Abbreviation:  Ir Med J     Publication Date:    2007 Nov-Dec
Date Detail:
Created Date:  2008-02-18     Completed Date:  2008-03-28     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0430275     Medline TA:  Ir Med J     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  631-2     Citation Subset:  IM    
St James's Hospital, Dublin.
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MeSH Terms
Anti-Retroviral Agents / administration & dosage,  adverse effects*
Drug Interactions
Methadone / administration & dosage,  adverse effects*
Narcotics / administration & dosage,  adverse effects*
Substance Abuse, Intravenous / rehabilitation
Torsades de Pointes / chemically induced*
Reg. No./Substance:
0/Anti-Retroviral Agents; 0/Narcotics; 76-99-3/Methadone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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