Document Detail

Methadone detoxification of tramadol dependence.
MedLine Citation:
PMID:  11027901     Owner:  NLM     Status:  MEDLINE    
Tramadol hydrochloride is a centrally acting analgesic with a partial affinity for the opiate receptor (mu), having an analgesic potency estimated to be one tenth that of morphine. While preclinical investigations suggested that abuse liability associated with tramadol use is low, there are increasing numbers of cases reported to the U.S. Food and Drug Administration of abuse, dependence, and withdrawal associated with tramadol use. A case of a patient with tramadol dependence requiring detoxification with methadone is presented. Acute management of significant tramadol dependence has not yet been reported in the literature. Long-term treatment issues are also discussed.
R J Leo; R Narendran; B DeGuiseppe
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of substance abuse treatment     Volume:  19     ISSN:  0740-5472     ISO Abbreviation:  J Subst Abuse Treat     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-11-20     Completed Date:  2000-11-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8500909     Medline TA:  J Subst Abuse Treat     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  297-9     Citation Subset:  IM    
Department of Psychiatry, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Erie County Medical Center, 462 Grider Street, Buffalo, NY 14215, USA.
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MeSH Terms
Acute Disease
Dose-Response Relationship, Drug
Methadone / therapeutic use*
Middle Aged
Opioid-Related Disorders / psychology,  rehabilitation*
Substance Withdrawal Syndrome / diagnosis,  rehabilitation
Tramadol* / adverse effects
Reg. No./Substance:
27203-92-5/Tramadol; 76-99-3/Methadone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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