| Methadone Toxicity and Possible Induction and Enhanced Elimination in a Premature Neonate. | |
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MedLine Citation:
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PMID: 22898875 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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INTRODUCTION: Reports describing methadone overdose in adult and pediatric patient populations are not uncommon. Reports in the preterm neonate patient population, however, are infrequent even though the utilization of methadone in that population continues to increase. Significant age-related pharmacokinetic differences complicate the management of methadone overdose in neonates, and literature involving methadone toxicokinetics and toxicodynamics in pediatric and neonate populations is largely limited. CASE REPORT: The clinical course and pharmacologic data of a massive methadone overdose in a 20-day-old male neonate is described, and a contemporary review of developmental pharmacology is presented. DISCUSSION: As clinicians continue to use methadone in neonates, they should be aware of the many significant peculiarities regarding its toxicology and pharmacology in that patient population. |
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Authors:
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Mathew George; Joseph P Kitzmiller; Michele Burns Ewald; Katherine A O'Donell; Melissa Lai Becter; Steve Salhanick |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-17 |
Journal Detail:
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Title: Journal of medical toxicology : official journal of the American College of Medical Toxicology Volume: - ISSN: 1937-6995 ISO Abbreviation: J Med Toxicol Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-8-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101284598 Medline TA: J Med Toxicol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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, Tappan, NY, USA, drmg456@gmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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