Document Detail

Methadone toxicity and possible induction and enhanced elimination in a premature neonate.
MedLine Citation:
PMID:  22898875     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Reports describing methadone overdose in adult and pediatric patient populations are not uncommon. Reports in the preterm neonate patient population, however, are infrequent even though the utilization of methadone in that population continues to increase. Significant age-related pharmacokinetic differences complicate the management of methadone overdose in neonates, and literature involving methadone toxicokinetics and toxicodynamics in pediatric and neonate populations is largely limited.
CASE REPORT: The clinical course and pharmacologic data of a massive methadone overdose in a 20-day-old male neonate is described, and a contemporary review of developmental pharmacology is presented.
DISCUSSION: As clinicians continue to use methadone in neonates, they should be aware of the many significant peculiarities regarding its toxicology and pharmacology in that patient population.
Mathew George; Joseph P Kitzmiller; Michele Burns Ewald; Katherine A O'Donell; Melissa Lai Becter; Steve Salhanick
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of medical toxicology : official journal of the American College of Medical Toxicology     Volume:  8     ISSN:  1937-6995     ISO Abbreviation:  J Med Toxicol     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-30     Completed Date:  2013-05-02     Revised Date:  2013-12-05    
Medline Journal Info:
Nlm Unique ID:  101284598     Medline TA:  J Med Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  432-5     Citation Subset:  IM    
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MeSH Terms
Cytochrome P-450 CYP3A / metabolism
Drug Overdose / therapy*
Infant, Newborn
Intensive Care Units
Methadone / blood,  pharmacokinetics*,  poisoning*,  urine
Phenobarbital / therapeutic use
Pyrrolidines / metabolism
Reg. No./Substance:
0/Pyrrolidines; 30223-73-5/2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine; EC P-450 CYP3A; UC6VBE7V1Z/Methadone; YQE403BP4D/Phenobarbital

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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