Document Detail

Methadone, QTc interval prolongation and torsade de pointes: Case reports offer the best understanding of this problem.
MedLine Citation:
PMID:  24167694     Owner:  NLM     Status:  PubMed-not-MEDLINE    
We reviewed the literature and found 31 adult cases and 1 newborn case of methadone-associated QTc interval prolongation and/or torsade de pointes (TdP). Parametric statistics may not be useful in studying this issue because methadone-associated TdP is a very rare event and, hence, "an extreme outlier" consistent with scalable randomness. We may have to rely upon narrative medicine in the form of case reports with all its limitations and hazards to provide our best understanding. We report risk factors for methadone-associated QTc interval prolongation and TdP based on review of published case reports. We believe both drug manufacturers and the FDA would better serve our patients and inform clinicians if they more readily reported drug-induced outliers such as methadone-associated TdP using a case report format.
W Victor R Vieweg; Mehrul Hasnain; Robert H Howland; Thomas Clausen; Jayanthi N Koneru; Christopher Kogut; Ericka L Breden Crouse; Jules C Hancox; Antony Fernandez; Ananda K Pandurangi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Therapeutic advances in psychopharmacology     Volume:  3     ISSN:  2045-1253     ISO Abbreviation:  Ther Adv Psychopharmacol     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-10-29     Completed Date:  2013-10-29     Revised Date:  2013-11-01    
Medline Journal Info:
Nlm Unique ID:  101555693     Medline TA:  Ther Adv Psychopharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  219-32     Citation Subset:  -    
Departments of Psychiatry and Internal Medicine, Virginia Commonwealth University, Richmond, Virginia, USA.
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