Document Detail

Methadone and perinatal outcomes: a prospective cohort study.
MedLine Citation:
PMID:  22340442     Owner:  NLM     Status:  MEDLINE    
AIMS:   Methadone use in pregnancy has been associated with adverse perinatal outcomes and neonatal abstinence syndrome (NAS). This study aimed to examine perinatal outcomes and NAS in relation to (i) concomitant drug use and (ii) methadone dose.
DESIGN:   Prospective cohort study.
SETTING:   Two tertiary care maternity hospitals.
PARTICIPANTS:   A total of 117 pregnant women on methadone maintenance treatment recruited between July 2009 and July 2010.
MEASUREMENTS:   Information on concomitant drug use was recorded with the Addiction Severity Index. Perinatal outcomes included pre-term birth (<37 weeks' gestation), small-for-gestational-age (<10th centile) and neonatal unit admission. NAS outcomes included: incidence of medically treated NAS, peak Finnegan score, cumulative dose of NAS treatment and duration of hospitalization.
FINDINGS:   Of the 114 liveborn infants 11 (9.6%) were born pre-term, 49 (42.9%) were small-for-gestational-age, 56 (49.1%) had a neonatal unit admission and 29 (25.4%) were treated medically for NAS. Neonates exposed to methadone-only had a shorter hospitalization than those exposed to methadone and concomitant drugs (median 5.0 days versus 6.0 days, P = 0.03). Neonates exposed to methadone doses ≥80 mg required higher cumulative doses of morphine treatment for NAS (median 13.2 mg versus 19.3 mg, P = 0.03). The incidence and duration of NAS did not differ between the two dosage groups.
CONCLUSIONS:   The incidence and duration of the neonatal abstinence syndrome is not associated with maternal methadone dose, but maternal opiate, benzodiazepine or cocaine use is associated with longer neonatal hospitalization.
Brian J Cleary; Maeve Eogan; Michael P O'Connell; Tom Fahey; Paul J Gallagher; Tom Clarke; Martin J White; Christine McDermott; Anne O'Sullivan; Deirdre Carmody; Justin Gleeson; Deirdre J Murphy
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-05-08
Journal Detail:
Title:  Addiction (Abingdon, England)     Volume:  107     ISSN:  1360-0443     ISO Abbreviation:  Addiction     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-11     Completed Date:  2012-10-09     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  9304118     Medline TA:  Addiction     Country:  England    
Other Details:
Languages:  eng     Pagination:  1482-92     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors, Addiction © 2012 Society for the Study of Addiction.
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MeSH Terms
Benzodiazepines / adverse effects
Dose-Response Relationship, Drug
Heroin Dependence / complications
Infant, Newborn
Infant, Small for Gestational Age
Intensive Care, Neonatal / statistics & numerical data
Marijuana Abuse / complications
Methadone / administration & dosage*
Narcotics / administration & dosage*
Neonatal Abstinence Syndrome / etiology*
Opiate Substitution Treatment / methods*
Opioid-Related Disorders / rehabilitation*
Pregnancy Complications / rehabilitation*
Pregnancy Outcome
Prenatal Care
Prospective Studies
Grant Support
G0900686//Medical Research Council
Reg. No./Substance:
0/Narcotics; 12794-10-4/Benzodiazepines; UC6VBE7V1Z/Methadone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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