| Methadone and metabolites in hair of methadone-assisted pregnant women and their infants. | |
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MedLine Citation:
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PMID: 22495425 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Methadone is the recommended pharmacotherapy for opioid-dependent pregnant women. The primary aims of this study were to determine whether a dose-concentration relationship exists between cumulative maternal methadone dose, methadone and metabolite concentrations in maternal hair during pregnancy and whether maternal hair methadone and metabolite concentrations predict neonatal outcomes. MATERIALS AND METHODS: Hair specimens were collected monthly from opioid-dependent mothers enrolled in methadone treatment and 4 of their infants. Hair specimens were segmented (3 cm), washed (maternal hair only), and analyzed for methadone, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP), and 2-ethyl-5-methyl-3,3-diphenylpyrroline by liquid chromatography tandem mass spectrometry. RESULTS: There was large intersubject variability and no dose-concentration relationship for cumulative methadone dose and methadone, EDDP, 2-ethyl-5-methyl-3,3-diphenylpyrroline, or total concentrations in hair. For individual women, a positive trend was noted for cumulative methadone dose and methadone and EDDP concentrations in hair. There was a positive linear trend for cumulative methadone dose and EDDP/methadone ratio in maternal hair, perhaps reflecting methadone's induction of its own metabolism. Maternal methadone concentrations were higher than those in infant hair, and infant EDDP hair concentrations were higher than those in maternal hair. Maternal methadone dose, and methadone and EDDP hair concentrations were not correlated with peak infant neonatal abstinence syndrome (NAS) scores, days to peak NAS, duration of NAS, time to NAS onset, birth length, head circumference, or amount of neonatal morphine pharmacotherapy. Maternal cumulative third trimester methadone dose was positively correlated with infant birth weight. CONCLUSIONS: Methadone and EDDP in pregnant women's hair are markers of methadone exposure and do not predict total methadone dose, nor neonatal outcomes from in utero methadone exposure. |
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Authors:
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Sarah K Himes; Robert S Goodwin; Colleen M Rock; Hendrée E Jones; Rolley E Johnson; Diana G Wilkins; Marilyn A Huestis |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural |
Journal Detail:
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Title: Therapeutic drug monitoring Volume: 34 ISSN: 1536-3694 ISO Abbreviation: Ther Drug Monit Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-05-16 Completed Date: 2013-03-11 Revised Date: 2013-06-06 |
Medline Journal Info:
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Nlm Unique ID: 7909660 Medline TA: Ther Drug Monit Country: United States |
Other Details:
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Languages: eng Pagination: 337-44 Citation Subset: IM |
Affiliation:
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Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Female Hair / chemistry, metabolism* Humans Infant, Newborn Methadone / metabolism*, therapeutic use Neonatal Abstinence Syndrome / diagnosis, metabolism Opiate Substitution Treatment / adverse effects, methods Opioid-Related Disorders / drug therapy, metabolism* Pregnancy Prenatal Exposure Delayed Effects / diagnosis, metabolism* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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DA 09096/DA/NIDA NIH HHS; DA 12220/DA/NIDA NIH HHS; DA 12403/DA/NIDA NIH HHS; M01RR-02719/RR/NCRR NIH HHS; R01 DA012220-04/DA/NIDA NIH HHS; Z01 DA000412-10/DA/NIDA NIH HHS; Z01 DA000412-11/DA/NIDA NIH HHS; ZIA DA000433-10/DA/NIDA NIH HHS; ZIA DA000433-11/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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76-99-3/Methadone |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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