| Metformin's effect on exercise and postexercise substrate oxidation. | |
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MedLine Citation:
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PMID: 20190353 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Exercise and metformin may prevent or delay Type 2 diabetes by, in part, raising the capacity for fat oxidation. Whether the addition of metformin has additive effects on fat oxidation during and after exercise is unknown. Therefore, the purpose of this study was to evaluate the effect of metformin on substrate oxidation during and after exercise. Using a double-blind, counter-balanced crossover design, substrate oxidation was assessed by indirect calorimetry in 15 individuals taking metformin (2,000 mg/d) and placebo for 8-10 d. Measurements were made during cycle exercise at 5 submaximal cycle workloads, starting at 30% peak work (W(peak)) and increasing by 10% every 8 min to 70% W(peak). Substrate oxidation was also measured for 50 min postexercise. Differences between conditions were assessed using analysis of variance with repeated measures, and values are reported as M + or - SE. During exercise, fat oxidation (0.19 + or - 0.03 vs. 0.15 + or - 0.01 g/min, p < .01) and percentage of energy from fat (32% + or - 3% vs. 28% + or - 3%, p < .01) were higher with metformin than with placebo. Postexercise, metformin slightly lowered fat oxidation (0.12 + or - 0.02 to 0.10 + or - 0.02 g/min, p < .01) compared with placebo. There was an inverse relationship between postexercise fat oxidation and the rate of fat oxidation during exercise (r = -.68, p < .05). In healthy individuals, metformin has opposing actions on fat oxidation during and after exercise. Whether the same effects are evident in insulin-resistant individuals remains to be determined. |
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Authors:
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Steven K Malin; Brooke R Stephens; Carrie G Sharoff; Todd A Hagobian; Stuart R Chipkin; Barry Braun |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of sport nutrition and exercise metabolism Volume: 20 ISSN: 1526-484X ISO Abbreviation: Int J Sport Nutr Exerc Metab Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-03-01 Completed Date: 2010-03-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100939812 Medline TA: Int J Sport Nutr Exerc Metab Country: United States |
Other Details:
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Languages: eng Pagination: 63-71 Citation Subset: IM |
Affiliation:
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Dept. of Kinesiology, University of Massachusetts-Amherst, Amherst, MA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Area Under Curve Bicycling / physiology* Calorimetry, Indirect Carbohydrate Metabolism / drug effects, physiology Cross-Over Studies Diabetes Mellitus, Type 2 / prevention & control Double-Blind Method Energy Metabolism / drug effects*, physiology Exercise Test Female Humans Hypoglycemic Agents / pharmacology* Lipid Metabolism / drug effects, physiology Male Metformin / pharmacology* Oxidation-Reduction Oxygen Consumption / drug effects*, physiology |
| Chemical | |
Reg. No./Substance:
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0/Hypoglycemic Agents; 657-24-9/Metformin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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