| Metformin therapy in diabetes: the role of cardioprotection. | |
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MedLine Citation:
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PMID: 23423523 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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In patients with diabetes mellitus, the incidence of cardiovascular disease is increased, and the outcome following cardiovascular events is worse. The antihyperglycemic drug metformin appears to limit cardiovascular death in patients with type 2 diabetes. Indeed, preclinical studies have demonstrated that metformin limits (myocardial) ischemia and reperfusion injury, independent from its glucose-lowering effect. This cardioprotection is mediated by activation of the Reperfusion Injury Salvage Kinase (RISK) pathway, activation of AMPK and by an increased formation of adenosine. In addition, metformin can modulate several cardiovascular risk factors and reduces the development of heart failure in murine models. Consequently, treatment with metformin might potentially improve cardiovascular outcome in patients at risk for myocardial ischemia, even if these patients do not have diabetes. In the current paper, we focus on the direct cardioprotective actions of metformin and the mechanisms that underlie these effects. |
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Authors:
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Saloua El Messaoudi; Gerard A Rongen; Niels P Riksen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current atherosclerosis reports Volume: 15 ISSN: 1534-6242 ISO Abbreviation: Curr Atheroscler Rep Publication Date: 2013 Apr |
Date Detail:
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Created Date: 2013-02-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100897685 Medline TA: Curr Atheroscler Rep Country: United States |
Other Details:
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Languages: eng Pagination: 314 Citation Subset: IM |
Affiliation:
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Department of Pharmacology-Toxicology 149, Radboud University Nijmegen Medical Center, PO Box 9101, 6500 HB, Nijmegen, The Netherlands, S.elMessaoudi@cardio.umcn.nl. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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