| Metformin therapy improves the menstrual pattern with minimal endocrine and metabolic effects in women with polycystic ovary syndrome. | |
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MedLine Citation:
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PMID: 9548159 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the clinical, hormonal, and biochemical effects of 4-6 months of metformin therapy in obese patients with polycystic ovary syndrome (PCOS). DESIGN: Prospective study. SETTING: The Gynecological Endocrine Unit of University Central Hospital, Oulu, Finland. PATIENT(S): Twenty obese patients with PCOS. INTERVENTION(S): Patients were treated with 0.5 g of metformin three times daily for 4-6 months. MAIN OUTCOME MEASURE(S): Clinical symptoms, menstrual pattern, and hirsutism, as well as serum concentrations of sex steroids, sex hormone-binding globulin (SHBG), gonadotropins, and lipids were assessed during the treatment. RESULT(S): Eleven women (68.8% of the women with menstrual disturbances) experienced more regular cycles during therapy. No changes in hirsutism, body mass index, or blood pressure occurred. The mean testosterone level was decreased significantly after 2 months of treatment but returned to the starting level by 4-6 months. Free testosterone levels decreased significantly during the treatment. There was no significant change in the levels of other sex steroids or lipids measured at 4-6 months of treatment. CONCLUSION(S): Metformin therapy is well tolerated by the majority of patients and may be clinically useful, especially in obese patients with PCOS and menstrual disturbances. |
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Authors:
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L C Morin-Papunen; R M Koivunen; A Ruokonen; H K Martikainen |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article |
Journal Detail:
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Title: Fertility and sterility Volume: 69 ISSN: 0015-0282 ISO Abbreviation: Fertil. Steril. Publication Date: 1998 Apr |
Date Detail:
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Created Date: 1998-05-01 Completed Date: 1998-05-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 691-6 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, University Central Hospital of Oulu, Finland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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17-alpha-Hydroxyprogesterone
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blood Adult Androstenedione / blood Blood Glucose / analysis Cohort Studies Dehydroepiandrosterone / blood Female Follicle Stimulating Hormone / blood Humans Hypoglycemic Agents / administration & dosage, pharmacology, therapeutic use* Insulin / blood Luteinizing Hormone / blood Menstruation / blood, drug effects*, physiology Metformin / administration & dosage, pharmacology, therapeutic use* Obesity / complications Polycystic Ovary Syndrome / blood, complications, drug therapy* Prospective Studies Sex Hormone-Binding Globulin / analysis Testosterone / blood Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Hypoglycemic Agents; 0/Sex Hormone-Binding Globulin; 11061-68-0/Insulin; 53-43-0/Dehydroepiandrosterone; 58-22-0/Testosterone; 63-05-8/Androstenedione; 657-24-9/Metformin; 68-96-2/17-alpha-Hydroxyprogesterone; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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