| Metformin restores the penile expression of nitric oxide synthase in high-fat-fed obese rats. | |
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MedLine Citation:
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PMID: 17314235 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Obesity is a well-known risk factor for erectile dysfunction, which is associated with reduced penile nitric oxide synthase (NOS) expression. Recently it was reported that metformin activates AMP-activated protein kinase (AMPK), which increases the expression of neuronal (n) NOS and endothelial (e) NOS. Thus, to evaluate whether metformin restores NOS expression in penile tissue, we measured penile expression of nNOS and eNOS after 4 weeks of metformin treatment (300 mg/kg/d) in 5-month-old high-fat-fed obese (HFO) rats. HFO rats have increased fat accumulation in visceral areas and marked suppression of nNOS and eNOS expression in penile tissue. However, metformin treatment decreased visceral fat deposition and restored nNOS and eNOS expression in penile tissue. The levels of AMPK and phosphorylated AMPK were also decreased in HFO rats but were subsequently elevated by metformin treatment. These results suggest that expression of NOS was suppressed by the high-fat diet but restored by metformin treatment. The effect of metformin on the expression of NOS may be associated with its activation of AMPK. |
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Authors:
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Yong-Woon Kim; So-Young Park; Jong-Yeon Kim; Jung-Yoon Huh; Woo-Sung Jeon; Chang-Jun Yoon; Sung-Su Yun; Ki-Hak Moon |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-02-21 |
Journal Detail:
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Title: Journal of andrology Volume: 28 ISSN: 0196-3635 ISO Abbreviation: J. Androl. Publication Date: 2007 Jul-Aug |
Date Detail:
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Created Date: 2007-06-25 Completed Date: 2007-10-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8106453 Medline TA: J Androl Country: United States |
Other Details:
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Languages: eng Pagination: 555-60 Citation Subset: IM |
Affiliation:
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Department of Urology, College of Medicine, Yeungnam University, 317-1 Daemyung-Dong, Nam-Gu, Daegu 705-035, Republic of Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenylate Kinase
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blood Adipose Tissue / anatomy & histology Animals Body Weight Dietary Fats* Male Metformin / therapeutic use* Nitric Oxide Synthase / genetics* Nitric Oxide Synthase Type III / genetics Obesity / enzymology*, etiology Organ Size Penis / enzymology* Rats Rats, Mutant Strains Rats, Sprague-Dawley Reverse Transcriptase Polymerase Chain Reaction |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 657-24-9/Metformin; EC 1.14.13.39/Nitric Oxide Synthase; EC 1.14.13.39/Nitric Oxide Synthase Type III; EC 2.7.4.3/Adenylate Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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