Document Detail


Metformin reduces vascular endothelial dysfunction caused by an acute glucose load in patients with hypertension.
MedLine Citation:
PMID:  23140261     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: To investigate the effects of a single dose of metformin (MF) on endothelium-dependent vasodilatation and serum antioxidant and free fatty acid levels in patients with primary hypertension (PH) after an acute glucose load.
MATERIALS AND METHODS: Patients with untreated PH were randomized to a no-metformin group (PH, n = 34) and a metformin group (PH+ MF, n = 28) who received a single dose of 500 mg metformin before testing. Healthy volunteers (n = 31) served as a control group. Brachial artery endothelium-dependent flow-mediated vasodilatation (FMD) was determined at 0, 1, 2 and 3 h after glucose load. Levels of serum superoxide dismutase (SOD), total antioxidant capacity (T-AOC), anti-superoxide anion free radical (AntiO2) and free fatty acids (FFA) were measured.
RESULTS: The FMD in the PH group decreased significantly 1 h after glucose load (PH: 10.9 ± 2.9% vs 13.67 ± 3.42% before glucose load). Metformin inhibited the effects of glucose load on FMD. At 1 h after acute glucose load, the concentrations of SOD, T-AOC and AntiO2 in the PH group decreased significantly compared with their fasting levels, and metformin inhibited the acute glucose load-induced decline in SOD and T-AOC levels.
CONCLUSIONS: Metformin can prevent transient endothelial dysfunction caused by acute glucose load in patients with PH.
Authors:
Ting-Xing Zhang; Jun-Xia Xu; Feng Peng; Da-Jun Chai; Jin-Xiu Lin
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2012-11-12
Journal Detail:
Title:  Blood pressure     Volume:  22     ISSN:  1651-1999     ISO Abbreviation:  Blood Press.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-18     Completed Date:  2013-08-27     Revised Date:  2013-11-14    
Medline Journal Info:
Nlm Unique ID:  9301454     Medline TA:  Blood Press     Country:  England    
Other Details:
Languages:  eng     Pagination:  106-13     Citation Subset:  IM    
Affiliation:
First Clinical Medical College of Fujian Medical University, 20 Chazhong Road, Fuzhou, Fujian Province, China.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antioxidants / metabolism
Brachial Artery / drug effects*,  physiopathology
Case-Control Studies
Endothelium, Vascular / drug effects*,  physiopathology
Fasting
Fatty Acids, Nonesterified / blood
Female
Glucose / diagnostic use*
Glucose Tolerance Test
Humans
Hypertension / blood,  physiopathology*
Hypoglycemic Agents / pharmacology*
Male
Metformin / pharmacology*
Middle Aged
Superoxide Dismutase / blood
Vasodilation / drug effects
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Fatty Acids, Nonesterified; 0/Hypoglycemic Agents; 50-99-7/Glucose; 657-24-9/Metformin; EC 1.15.1.1/Superoxide Dismutase

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