Document Detail

Metformin in the treatment of clomiphene citrate-resistant women with high BMI and primary infertility: clinical results and reproductive outcome.
MedLine Citation:
PMID:  16147697     Owner:  NLM     Status:  MEDLINE    
The objective of this study was to evaluate the clinical and reproductive outcome in clomiphene-citrate (CC)-resistant women with high body mass index (BMI) and primary infertility. This was a case series based at the King Hussein Medical center, Amman, Jordan. Nineteen CC-resistant women with polycystic ovary syndrome (PCOS) who had high BMI and primary infertility were studied. All women received metformin monotherapy; 850 mg twice daily for a period of 6 months. If pregnancy occurred, metformin was continued for the first 12 weeks of pregnancy. The main outcome measures were a reduction in the BMI, resumption of regular menses, ovulation and pregnancy rates. Resumption of regular cycles was observed in 13 of 19 (68.4%) women. Ovulation and pregnancy were achieved in 9 (47.4%) and 6 (31.6%) of the 19 women, respectively. A significant reduction in the body weight after treatment reflected by a significant reduction in the BMI was noted. Metformin monotherapy is effective in CC-resistant women with morbid obesity and primary infertility and should be considered as first-line treatment in these patients.
H S Qublan; H Y Malkawi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology     Volume:  25     ISSN:  0144-3615     ISO Abbreviation:  J Obstet Gynaecol     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-09-08     Completed Date:  2005-12-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309140     Medline TA:  J Obstet Gynaecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  55-9     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, Infirtility clinic, Royal Medical Service, King Hussein Medical Center, Amman, Jordan.
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MeSH Terms
Body Mass Index
Drug Resistance
Hypoglycemic Agents / administration & dosage*
Infertility, Female / therapy*
Metformin / administration & dosage*
Obesity / complications*,  drug therapy
Ovulation Induction
Polycystic Ovary Syndrome / complications,  drug therapy
Pregnancy Outcome
Treatment Outcome
Weight Loss
Reg. No./Substance:
0/Hypoglycemic Agents; 657-24-9/Metformin; 911-45-5/Clomiphene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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