Document Detail

Metformin hydrochloride and recurrent miscarriage in a woman with polycystic ovary syndrome.
MedLine Citation:
PMID:  16647382     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To report the effect of metformin treatment on a patient with recurrent miscarriage (RM) and polycystic ovary syndrome (PCOS). DESIGN: Case report. SETTING: University department of obstetrics and gynecology, Italy. PATIENT(S): A woman complaining of RM who had PCOS and insulin resistance. INTERVENTION(S): Clinical, biochemical, and instrumental assessments. MAIN OUTCOME MEASURE(S): Administration of metformin hydrochloride before and throughout pregnancy. RESULT(S): After 3 months of treatment, the patient became pregnant. The pregnancy had a physiologic development, and at 39 weeks of gestation, the patient spontaneously delivered a healthy infant. CONCLUSION(S): Metformin has shown to be effective in an insulin-resistant PCOS woman with RM.
Stefano Palomba; Angela Falbo; Francesco Orio; Tiziana Russo; Achille Tolino; Fulvio Zullo
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Fertility and sterility     Volume:  85     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-05-01     Completed Date:  2006-05-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1511.e3-5     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University Magna Graecia of Catanzaro, Italy.
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MeSH Terms
Abortion, Habitual / prevention & control*
Diabetes, Gestational / prevention & control*
Hypoglycemic Agents / administration & dosage
Metformin / administration & dosage*
Polycystic Ovary Syndrome / drug therapy*
Treatment Outcome
Reg. No./Substance:
0/Hypoglycemic Agents; 657-24-9/Metformin

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