| Metformin and heart failure: never say never again. | |
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MedLine Citation:
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PMID: 22149365 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Metformin represents the cornerstone of treatment for type 2 diabetes mellitus. Traditionally, heart failure (HF) was considered a contraindication to its use. However, more recent evidence has shown that this should no longer be the case. Indeed, studies have demonstrated that metformin may even reduce the risk of incident HF and mortality in diabetic patients, while improving up to 2-year survival rates in those with HF. In addition, it appears to exert cardioprotective actions. Although longer follow-up data and more explicit information about the situation in patients with very advanced HF are needed, the cardiac safety of metformin has profound clinical implications and may be anticipated to further encourage its widespread use. |
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Authors:
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Nikolaos Papanas; Efstratios Maltezos; Dimitri P Mikhailidis |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Expert opinion on pharmacotherapy Volume: 13 ISSN: 1744-7666 ISO Abbreviation: Expert Opin Pharmacother Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100897346 Medline TA: Expert Opin Pharmacother Country: England |
Other Details:
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Languages: eng Pagination: 1-8 Citation Subset: IM |
Affiliation:
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Democritus University of Thrace, University Hospital of Alexandroupolis, Outpatient Clinic of Obesity, Diabetes and Metabolism, 68100 Alexandroupolis , Greece +30 25310 39000 ; +30 25510 74723 ; papanasnikos@yahoo.gr. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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