Document Detail

Metformin and exercise: no additive effect on blood lactate levels in health volunteers.
MedLine Citation:
PMID:  9047091     Owner:  NLM     Status:  MEDLINE    
Metformin administration has been associated with substantial rises in blood lactate concentrations in individual Type 2 diabetic patients. Exercise also leads to increases in blood lactate levels. The objective of this study was to determine whether metformin administration augments the rise in plasma lactate concentrations during intermittent exercise in healthy subjects, when compared to placebo. Twelve healthy males (age 28 +/- 5 years, body mass index 22.7 +/- 1.3 kg m-2) took either 1.7 g metformin or placebo daily for 4 consecutive days before being subjected to strenuous intermittent exercise. On the morning of the fourth day exercise was performed on an upright bicycle ergometer at a work load of 200 W for 2 min alternating with 2 min rest for an overall duration of 60 min. Maximal plasma lactate levels during exercise (metformin: 4.1 +/- 2.6 mmol l(-)1, placebo: 4.5 +/- 2.6 mmol (l-1)), areas under the plasma lactate curve (207 +/- 121 vs 222 +/- 133 mmol l(-1) h(-1), blood pyruvate levels at the end of exercise (0.06 +/- 0.04 vs 0.07 +/- 0.04 mmol l(-1)), lactate/pyruvate ratio (65 +/- 41 vs 60 +/- 36), serum insulin (25.4 +/- 8.9 vs 32.3 +/- 13.0 pmol l(-1)), and plasma glucose (4.4 +/- 0.3 vs 4.5 +/- 0.3 mmol l(-1)) did not differ significantly between metformin and placebo administration. Administration of metformin did not lead to an augmented rise in endogenous plasma lactate concentrations during intermittent exercise in healthy fasting subjects under the experimental design chosen.
U Gudat; G Convent; L Heinemann
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Diabetic medicine : a journal of the British Diabetic Association     Volume:  14     ISSN:  0742-3071     ISO Abbreviation:  Diabet. Med.     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-07-18     Completed Date:  1997-07-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8500858     Medline TA:  Diabet Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  138-42     Citation Subset:  IM    
Department of Metabolic Diseases and Nutrition, (WHO Collaborating Centre for Diabetes), Heinrich-Heine University Düsseldorf, Germany.
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MeSH Terms
Analysis of Variance
Blood Pressure / physiology
C-Peptide / blood,  metabolism
Exercise / physiology*
Heart Rate / physiology
Hydrogen-Ion Concentration
Hypoglycemic Agents / adverse effects,  pharmacology*
Insulin / blood,  metabolism
Lactates / blood*,  metabolism
Metformin / adverse effects,  pharmacology*
Pyruvates / blood,  metabolism
Reg. No./Substance:
0/C-Peptide; 0/Hypoglycemic Agents; 0/Lactates; 0/Pyruvates; 11061-68-0/Insulin; 657-24-9/Metformin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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