| Metformin and exercise: no additive effect on blood lactate levels in health volunteers. | |
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MedLine Citation:
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PMID: 9047091 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Metformin administration has been associated with substantial rises in blood lactate concentrations in individual Type 2 diabetic patients. Exercise also leads to increases in blood lactate levels. The objective of this study was to determine whether metformin administration augments the rise in plasma lactate concentrations during intermittent exercise in healthy subjects, when compared to placebo. Twelve healthy males (age 28 +/- 5 years, body mass index 22.7 +/- 1.3 kg m-2) took either 1.7 g metformin or placebo daily for 4 consecutive days before being subjected to strenuous intermittent exercise. On the morning of the fourth day exercise was performed on an upright bicycle ergometer at a work load of 200 W for 2 min alternating with 2 min rest for an overall duration of 60 min. Maximal plasma lactate levels during exercise (metformin: 4.1 +/- 2.6 mmol l(-)1, placebo: 4.5 +/- 2.6 mmol (l-1)), areas under the plasma lactate curve (207 +/- 121 vs 222 +/- 133 mmol l(-1) h(-1), blood pyruvate levels at the end of exercise (0.06 +/- 0.04 vs 0.07 +/- 0.04 mmol l(-1)), lactate/pyruvate ratio (65 +/- 41 vs 60 +/- 36), serum insulin (25.4 +/- 8.9 vs 32.3 +/- 13.0 pmol l(-1)), and plasma glucose (4.4 +/- 0.3 vs 4.5 +/- 0.3 mmol l(-1)) did not differ significantly between metformin and placebo administration. Administration of metformin did not lead to an augmented rise in endogenous plasma lactate concentrations during intermittent exercise in healthy fasting subjects under the experimental design chosen. |
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Authors:
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U Gudat; G Convent; L Heinemann |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Diabetic medicine : a journal of the British Diabetic Association Volume: 14 ISSN: 0742-3071 ISO Abbreviation: Diabet. Med. Publication Date: 1997 Feb |
Date Detail:
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Created Date: 1997-07-18 Completed Date: 1997-07-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8500858 Medline TA: Diabet Med Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 138-42 Citation Subset: IM |
Affiliation:
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Department of Metabolic Diseases and Nutrition, (WHO Collaborating Centre for Diabetes), Heinrich-Heine University Düsseldorf, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Blood Pressure / physiology C-Peptide / blood, metabolism Exercise / physiology* Heart Rate / physiology Humans Hydrogen-Ion Concentration Hypoglycemic Agents / adverse effects, pharmacology* Insulin / blood, metabolism Lactates / blood*, metabolism Male Metformin / adverse effects, pharmacology* Oxidation-Reduction Pyruvates / blood, metabolism |
| Chemical | |
Reg. No./Substance:
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0/C-Peptide; 0/Hypoglycemic Agents; 0/Lactates; 0/Pyruvates; 11061-68-0/Insulin; 657-24-9/Metformin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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