Document Detail

Metformin decreases plasma insulin levels and systolic blood pressure in spontaneously hypertensive rats.
MedLine Citation:
PMID:  7943368     Owner:  NLM     Status:  MEDLINE    
To determine the relationship between hyperinsulinemia and hypertension in spontaneously hypertensive rats (SHR), the antihyperglycemic agent metformin was administered to SHR and their Wistar-Kyoto (WKY) controls, and its effects on plasma insulin levels and blood pressure were examined. Five-week-old rats were started on oral metformin treatment (350, which was gradually increased to 500 over a 2-wk period). Metformin treatment caused sustained decreases in plasma insulin levels in the SHR (27.1 +/- 2.3 vs. untreated SHR 53.5 +/- 2.7 microU/ml, P < 0.001) without having any effect in the WKY (30.7 +/- 2.2 vs. untreated WKY 37.8 +/- 1.6 microU/ml, P > 0.05). The treatment did not affect the plasma glucose levels in any group. Metformin treatment also attenuated the increase in systolic blood pressure in the SHR (157 +/- 6.0 vs. untreated SHR 196 +/- 9.0 mmHg, P < 0.001) but had no effect in the WKY (134 +/- 3 vs. untreated WKY 136 +/- 4 mmHg, P > 0.05). Furthermore, raising plasma insulin levels in the metformin-treated SHR to levels that existed in the untreated SHR reversed the effect of metformin on blood pressure (189 +/- 3 vs. untreated SHR 208 +/- 5.0 mmHg, P > 0.05). These findings suggest that either hyperinsulinemia may contribute toward the increase in blood pressure in the SHR or that the underlying mechanism is closely associated with the expression of both these disorders.
S Verma; S Bhanot; J H McNeill
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  267     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1994-11-18     Completed Date:  1994-11-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H1250-3     Citation Subset:  IM    
Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada.
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MeSH Terms
Aging / physiology*
Blood Glucose / metabolism
Body Weight
Hypertension / physiopathology*
Insulin / blood*,  secretion
Metformin / pharmacology*
Multivariate Analysis
Rats, Inbred SHR
Rats, Inbred WKY
Reference Values
Systole / drug effects*
Reg. No./Substance:
0/Blood Glucose; 11061-68-0/Insulin; 657-24-9/Metformin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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