| Metformin is associated with improved left ventricular diastolic function measured by tissue Doppler imaging in patients with diabetes. | |
| | |
MedLine Citation:
|
PMID: 20679358 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To examine the association between selected glucose-lowering medications and left ventricular (LV) diastolic function in patients with diabetes. DESIGN: Retrospective cohort study (years 2005-2008). METHODS: Echocardiograms of 242 patients with diabetes undergoing coronary angiography were analyzed. All patients had an LV ejection fraction (LVEF) ≥20% and were without atrial fibrillation, bundle branch block, valvular disease, or cardiac pacemaker. Patients were grouped according to the use of metformin (n=56), sulfonylureas (n=43), insulin (n=61), and combination treatment (n=82). RESULTS: Mean age (66±10 years) and mean LVEF (45±11%) were similar across the groups. Mean isovolumic relaxation time (IVRT) was 66±31, 79±42, 69±23, and 66±29 ms in metformin, sulfonylureas, insulin, and combination treatment groups respectively (P=0.4). Mean early diastolic longitudinal tissue velocity (e') was 5.3±1.6, 4.6±1.6, 5.3±1.8, and 5.4±1.7 cm/s in metformin, sulfonylureas, insulin, and combination treatment groups (P=0.04). In adjusted linear regression models, the use of metformin was associated with a shorter IVRT (parameter estimate -9.9 ms, P=0.049) and higher e' (parameter estimate +0.52 cm/s, P=0.03), compared with no use of metformin. The effects of metformin were not altered by concomitant use of sulfonylureas or insulin (P for interactions >0.4). CONCLUSIONS: The use of metformin is associated with improved LV relaxation, as compared with no use of metformin. |
| | |
Authors:
|
Charlotte Andersson; Peter Søgaard; Søren Hoffmann; Peter R Hansen; Allan Vaag; Atheline Major-Pedersen; Thomas Fritz Hansen; Jan Bech; Lars Køber; Christian Torp-Pedersen; Gunnar H Gislason |
Related Documents
:
|
20798858 - Long-term effects of metformin and lifestyle modification on nonalcoholic fatty liver d... 12809958 - A randomized, double-blind, placebo-controlled, clinical trial of the effects of piogli... 19019358 - Endothelial function and insulin resistance in polycystic ovary syndrome: the effects o... 17335818 - N-acetyl cysteine vs. metformin in treatment of clomiphene citrate-resistant polycystic... 15663878 - Using survey data for diabetes surveillance among minority populations: a report of the... 6337138 - Effects of insulin on phenylephrine-induced activation of phosphorylase and phosphatidy... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-02 |
Journal Detail:
|
Title: European journal of endocrinology / European Federation of Endocrine Societies Volume: 163 ISSN: 1479-683X ISO Abbreviation: Eur. J. Endocrinol. Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-09-17 Completed Date: 2010-10-06 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9423848 Medline TA: Eur J Endocrinol Country: England |
Other Details:
|
Languages: eng Pagination: 593-9 Citation Subset: IM |
Affiliation:
|
Department of Cardiology, Copenhagen University Hospital, Gentofte, Copenhagen, Denmark. ca@heart.dk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Cohort Studies Coronary Angiography Diabetes Mellitus, Type 2 / drug therapy* Echocardiography Humans Hypoglycemic Agents / pharmacology*, therapeutic use* Male Metformin / pharmacology*, therapeutic use* Middle Aged Retrospective Studies Ventricular Function, Left / drug effects* |
| Chemical | |
Reg. No./Substance:
|
0/Hypoglycemic Agents; 657-24-9/Metformin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Adiposity and Insulin Resistance Correlate with Telomere Length in Middle-aged Arabs: The Influence ...
Next Document: Proinsulin levels in patients with pancreatic diabetes are associated with functional changes in ins...