Document Detail

Metformin-associated lactic acidosis.
MedLine Citation:
PMID:  11267815     Owner:  NLM     Status:  MEDLINE    
In 1995, the oral antihyperglycemic agent, metformin, was introduced in the United States for treating diabetes mellitus. Rare cases of metformin-associated lactic acidosis caused by the accumulation of the drug in patients with renal dysfunction have been described, although a detailed time course of the resulting metabolic derangements has not been reported. A case of metformin-associated lactic acidosis is presented along with key serial laboratory abnormalities observed during the treatment phase. The patient made a complete recovery following therapy with hemodialysis and supportive care.
J A Kruse
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of emergency medicine     Volume:  20     ISSN:  0736-4679     ISO Abbreviation:  J Emerg Med     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-03-27     Completed Date:  2001-05-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8412174     Medline TA:  J Emerg Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  267-72     Citation Subset:  IM    
Detroit Receiving Hospital and Wayne State University School of Medicine, Detroit, Michigan 48201, USA.
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MeSH Terms
Acidosis, Lactic / chemically induced*,  physiopathology,  therapy
Hypoglycemic Agents / adverse effects*
Metformin / adverse effects*
Renal Dialysis
Reg. No./Substance:
0/Hypoglycemic Agents; 657-24-9/Metformin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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